Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers

Abstract Purpose We aimed to examine the characteristics of imaging findings of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) in the lungs of smokers compared with those of non-smokers. Materials and methods We included seven cases of AIS and 20 cases of MIA in lungs of sm...

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Autores principales:	Haruto Sugawara, Hirokazu Watanabe, Akira Kunimatsu, Osamu Abe, Shun-ichi Watanabe, Yasushi Yatabe, Masahiko Kusumoto
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/4f99626b257746d6ac8bd13596dc7fff
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spelling	oai:doaj.org-article:4f99626b257746d6ac8bd13596dc7fff2021-11-21T12:33:33ZAdenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers10.1186/s12880-021-00705-11471-2342https://doaj.org/article/4f99626b257746d6ac8bd13596dc7fff2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00705-1https://doaj.org/toc/1471-2342Abstract Purpose We aimed to examine the characteristics of imaging findings of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) in the lungs of smokers compared with those of non-smokers. Materials and methods We included seven cases of AIS and 20 cases of MIA in lungs of smokers (pack-years ≥ 20) and the same number of cases of AIS and MIA in lungs of non-smokers (pack-years = 0). We compared the diameter of the entire lesion and solid component measured on computed tomography (CT) images, pathological size and invasive component diameter measured from pathological specimens, and CT values of the entire lesion and ground-glass opacity (GGO) portions between the smoker and non-smoker groups. Results The diameters of AIS and MIA on CT images and pathological specimens of the smoker group were significantly larger than those of the non-smoker group (p = 0.036 and 0.008, respectively), whereas there was no significant difference in the diameter of the solid component on CT images or invasive component of pathological specimens between the two groups. Additionally, mean CT values of the entire lesion and GGO component of the lesions in the smoker group were significantly lower than those in the non-smoker group (p = 0.036 and 0.040, respectively). Conclusion AIS and MIA in smoker’s lung tended to have larger lesion diameter and lower internal CT values compared with lesions in non-smoker’s lung. This study calls an attention on smoking status in CT-based diagnosis for early stage adenocarcinoma.Haruto SugawaraHirokazu WatanabeAkira KunimatsuOsamu AbeShun-ichi WatanabeYasushi YatabeMasahiko KusumotoBMCarticleMedical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Haruto Sugawara Hirokazu Watanabe Akira Kunimatsu Osamu Abe Shun-ichi Watanabe Yasushi Yatabe Masahiko Kusumoto Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
description	Abstract Purpose We aimed to examine the characteristics of imaging findings of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) in the lungs of smokers compared with those of non-smokers. Materials and methods We included seven cases of AIS and 20 cases of MIA in lungs of smokers (pack-years ≥ 20) and the same number of cases of AIS and MIA in lungs of non-smokers (pack-years = 0). We compared the diameter of the entire lesion and solid component measured on computed tomography (CT) images, pathological size and invasive component diameter measured from pathological specimens, and CT values of the entire lesion and ground-glass opacity (GGO) portions between the smoker and non-smoker groups. Results The diameters of AIS and MIA on CT images and pathological specimens of the smoker group were significantly larger than those of the non-smoker group (p = 0.036 and 0.008, respectively), whereas there was no significant difference in the diameter of the solid component on CT images or invasive component of pathological specimens between the two groups. Additionally, mean CT values of the entire lesion and GGO component of the lesions in the smoker group were significantly lower than those in the non-smoker group (p = 0.036 and 0.040, respectively). Conclusion AIS and MIA in smoker’s lung tended to have larger lesion diameter and lower internal CT values compared with lesions in non-smoker’s lung. This study calls an attention on smoking status in CT-based diagnosis for early stage adenocarcinoma.
format	article
author	Haruto Sugawara Hirokazu Watanabe Akira Kunimatsu Osamu Abe Shun-ichi Watanabe Yasushi Yatabe Masahiko Kusumoto
author_facet	Haruto Sugawara Hirokazu Watanabe Akira Kunimatsu Osamu Abe Shun-ichi Watanabe Yasushi Yatabe Masahiko Kusumoto
author_sort	Haruto Sugawara
title	Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
title_short	Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
title_full	Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
title_fullStr	Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
title_full_unstemmed	Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
title_sort	adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4f99626b257746d6ac8bd13596dc7fff
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Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers

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