Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review

Spinal glioblastoma multiforme (GBM) that originates from the conus medullaris is rare as only 28 cases have been reported. It is highly aggressive and usually initially presents with low back pain, sensory and motor impairment of the lower extremities, and bladder dysfunction. We herein report a un...

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Autores principales:	Yu Hu, Wumeng Yin, Junpeng Ma, Jiagang Liu, Siqing Huang, Haifeng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	case report conus medullaris intracranial hypertension leptomeningeal dissemination spinal glioblastoma multiforme tuberculous meningitis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4f9b9c30629d41a28ddb10f66350e48e
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spelling	oai:doaj.org-article:4f9b9c30629d41a28ddb10f66350e48e2021-11-19T10:42:03ZGlioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review2589-61132589-612110.4103/glioma.glioma_15_21https://doaj.org/article/4f9b9c30629d41a28ddb10f66350e48e2021-01-01T00:00:00Zhttp://www.jglioma.com/article.asp?issn=2589-6113;year=2021;volume=4;issue=3;spage=57;epage=61;aulast=Huhttps://doaj.org/toc/2589-6113https://doaj.org/toc/2589-6121Spinal glioblastoma multiforme (GBM) that originates from the conus medullaris is rare as only 28 cases have been reported. It is highly aggressive and usually initially presents with low back pain, sensory and motor impairment of the lower extremities, and bladder dysfunction. We herein report a unique case of GBM in the conus medullaris with leptomeningeal dissemination that initially presented with increased intracranial pressure without hydrocephalus. The patient was first diagnosed with tuberculous meningitis and received antituberculosis therapy, but the symptoms did not resolve and even worsened. Subsequent radiological imaging clearly disclosed an intramedullary lesion at the T12 level with the progression of leptomeningeal enhancement. Subtotal resection of the intramedullary lesion was performed, and pathological examination revealed the presence of GBM. To our knowledge, our case was the first with holocordal and intracranial leptomeningeal dissemination that initially presented with intracranial hypertension in the absence of hydrocephalus. Awareness of this unusually lethal condition is significant for proper diagnosis, timely treatment, and consideration of clinical prognosis.Yu HuWumeng YinJunpeng MaJiagang LiuSiqing HuangHaifeng ChenWolters Kluwer Medknow Publicationsarticlecase reportconus medullarisintracranial hypertensionleptomeningeal disseminationspinal glioblastoma multiformetuberculous meningitisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENGlioma, Vol 4, Iss 3, Pp 57-61 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case report conus medullaris intracranial hypertension leptomeningeal dissemination spinal glioblastoma multiforme tuberculous meningitis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	case report conus medullaris intracranial hypertension leptomeningeal dissemination spinal glioblastoma multiforme tuberculous meningitis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yu Hu Wumeng Yin Junpeng Ma Jiagang Liu Siqing Huang Haifeng Chen Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
description	Spinal glioblastoma multiforme (GBM) that originates from the conus medullaris is rare as only 28 cases have been reported. It is highly aggressive and usually initially presents with low back pain, sensory and motor impairment of the lower extremities, and bladder dysfunction. We herein report a unique case of GBM in the conus medullaris with leptomeningeal dissemination that initially presented with increased intracranial pressure without hydrocephalus. The patient was first diagnosed with tuberculous meningitis and received antituberculosis therapy, but the symptoms did not resolve and even worsened. Subsequent radiological imaging clearly disclosed an intramedullary lesion at the T12 level with the progression of leptomeningeal enhancement. Subtotal resection of the intramedullary lesion was performed, and pathological examination revealed the presence of GBM. To our knowledge, our case was the first with holocordal and intracranial leptomeningeal dissemination that initially presented with intracranial hypertension in the absence of hydrocephalus. Awareness of this unusually lethal condition is significant for proper diagnosis, timely treatment, and consideration of clinical prognosis.
format	article
author	Yu Hu Wumeng Yin Junpeng Ma Jiagang Liu Siqing Huang Haifeng Chen
author_facet	Yu Hu Wumeng Yin Junpeng Ma Jiagang Liu Siqing Huang Haifeng Chen
author_sort	Yu Hu
title	Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
title_short	Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
title_full	Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
title_fullStr	Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
title_full_unstemmed	Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
title_sort	glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: a case report and literature review
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/4f9b9c30629d41a28ddb10f66350e48e
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Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review

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