Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting

The hippocampus has long been considered as a key structure for memory processes. Multilevel alterations of hippocampal function have been identified as a common denominator of memory impairments in a number of psychiatric and neurodegenerative diseases. For many years, the glutamatergic and choline...

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Autores principales:	Candice M. Roux, Marianne Leger, Thomas Freret
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	5-HT<sub>4</sub>Rs serotonin hippocampus memory disorders therapeutic target synaptic plasticity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4f9ead232fd24891a80d2b6079e845b9
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spelling	oai:doaj.org-article:4f9ead232fd24891a80d2b6079e845b92021-11-11T17:28:21ZMemory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting10.3390/ijms2221120821422-00671661-6596https://doaj.org/article/4f9ead232fd24891a80d2b6079e845b92021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12082https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The hippocampus has long been considered as a key structure for memory processes. Multilevel alterations of hippocampal function have been identified as a common denominator of memory impairments in a number of psychiatric and neurodegenerative diseases. For many years, the glutamatergic and cholinergic systems have been the main targets of therapeutic treatments against these symptoms. However, the high rate of drug development failures has left memory impairments on the sideline of current therapeutic strategies. This underscores the urgent need to focus on new therapeutic targets for memory disorders, such as type 4 serotonin receptors (5-HT<sub>4</sub>Rs). Ever since the discovery of their expression in the hippocampus, 5-HT<sub>4</sub>Rs have gained growing interest for potential use in the treatment of learning and memory impairments. To date, much of the researched information gathered by scientists from both animal models and humans converge on pro-mnesic and anti-amnesic properties of 5-HT<sub>4</sub>Rs activation, although the mechanisms at work require more work to be fully understood. This review addresses a fundamental, yet poorly understood set of evidence of the potential of 5-HT<sub>4</sub>Rs to re-establish or limit hippocampal alterations related to neurological diseases. Most importantly, the potential of 5-HT<sub>4</sub>Rs is translated by refining hypotheses regarding the benefits of their activation in memory disorders at the hippocampal level.Candice M. RouxMarianne LegerThomas FreretMDPI AGarticle5-HT<sub>4</sub>Rsserotoninhippocampusmemory disorderstherapeutic targetsynaptic plasticityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12082, p 12082 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	5-HT<sub>4</sub>Rs serotonin hippocampus memory disorders therapeutic target synaptic plasticity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	5-HT<sub>4</sub>Rs serotonin hippocampus memory disorders therapeutic target synaptic plasticity Biology (General) QH301-705.5 Chemistry QD1-999 Candice M. Roux Marianne Leger Thomas Freret Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting
description	The hippocampus has long been considered as a key structure for memory processes. Multilevel alterations of hippocampal function have been identified as a common denominator of memory impairments in a number of psychiatric and neurodegenerative diseases. For many years, the glutamatergic and cholinergic systems have been the main targets of therapeutic treatments against these symptoms. However, the high rate of drug development failures has left memory impairments on the sideline of current therapeutic strategies. This underscores the urgent need to focus on new therapeutic targets for memory disorders, such as type 4 serotonin receptors (5-HT<sub>4</sub>Rs). Ever since the discovery of their expression in the hippocampus, 5-HT<sub>4</sub>Rs have gained growing interest for potential use in the treatment of learning and memory impairments. To date, much of the researched information gathered by scientists from both animal models and humans converge on pro-mnesic and anti-amnesic properties of 5-HT<sub>4</sub>Rs activation, although the mechanisms at work require more work to be fully understood. This review addresses a fundamental, yet poorly understood set of evidence of the potential of 5-HT<sub>4</sub>Rs to re-establish or limit hippocampal alterations related to neurological diseases. Most importantly, the potential of 5-HT<sub>4</sub>Rs is translated by refining hypotheses regarding the benefits of their activation in memory disorders at the hippocampal level.
format	article
author	Candice M. Roux Marianne Leger Thomas Freret
author_facet	Candice M. Roux Marianne Leger Thomas Freret
author_sort	Candice M. Roux
title	Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting
title_short	Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting
title_full	Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting
title_fullStr	Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting
title_full_unstemmed	Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting
title_sort	memory disorders related to hippocampal function: the interest of 5-ht<sub>4</sub>rs targeting
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f9ead232fd24891a80d2b6079e845b9
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Memory Disorders Related to Hippocampal Function: The Interest of 5-HT<sub>4</sub>Rs Targeting

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