Conserved phosphorylation hotspots in eukaryotic protein domain families

Protein phosphorylation has various regulatory functions. Here, the authors map 241 phosphorylation hotspot regions across 40 eukaryotic species, showing that they are enriched at interfaces and near catalytic residues, and enable the discovery of functionally important phospho-sites.

Guardado en:

Detalles Bibliográficos
Autores principales:	Marta J. Strumillo, Michaela Oplová, Cristina Viéitez, David Ochoa, Mohammed Shahraz, Bede P. Busby, Richelle Sopko, Romain A. Studer, Norbert Perrimon, Vikram G. Panse, Pedro Beltrao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4fa001d5e18b4538b71b32f9cc484470
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4fa001d5e18b4538b71b32f9cc484470
record_format	dspace
spelling	oai:doaj.org-article:4fa001d5e18b4538b71b32f9cc4844702021-12-02T15:36:02ZConserved phosphorylation hotspots in eukaryotic protein domain families10.1038/s41467-019-09952-x2041-1723https://doaj.org/article/4fa001d5e18b4538b71b32f9cc4844702019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09952-xhttps://doaj.org/toc/2041-1723Protein phosphorylation has various regulatory functions. Here, the authors map 241 phosphorylation hotspot regions across 40 eukaryotic species, showing that they are enriched at interfaces and near catalytic residues, and enable the discovery of functionally important phospho-sites.Marta J. StrumilloMichaela OplováCristina ViéitezDavid OchoaMohammed ShahrazBede P. BusbyRichelle SopkoRomain A. StuderNorbert PerrimonVikram G. PansePedro BeltraoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta J. Strumillo Michaela Oplová Cristina Viéitez David Ochoa Mohammed Shahraz Bede P. Busby Richelle Sopko Romain A. Studer Norbert Perrimon Vikram G. Panse Pedro Beltrao Conserved phosphorylation hotspots in eukaryotic protein domain families
description	Protein phosphorylation has various regulatory functions. Here, the authors map 241 phosphorylation hotspot regions across 40 eukaryotic species, showing that they are enriched at interfaces and near catalytic residues, and enable the discovery of functionally important phospho-sites.
format	article
author	Marta J. Strumillo Michaela Oplová Cristina Viéitez David Ochoa Mohammed Shahraz Bede P. Busby Richelle Sopko Romain A. Studer Norbert Perrimon Vikram G. Panse Pedro Beltrao
author_facet	Marta J. Strumillo Michaela Oplová Cristina Viéitez David Ochoa Mohammed Shahraz Bede P. Busby Richelle Sopko Romain A. Studer Norbert Perrimon Vikram G. Panse Pedro Beltrao
author_sort	Marta J. Strumillo
title	Conserved phosphorylation hotspots in eukaryotic protein domain families
title_short	Conserved phosphorylation hotspots in eukaryotic protein domain families
title_full	Conserved phosphorylation hotspots in eukaryotic protein domain families
title_fullStr	Conserved phosphorylation hotspots in eukaryotic protein domain families
title_full_unstemmed	Conserved phosphorylation hotspots in eukaryotic protein domain families
title_sort	conserved phosphorylation hotspots in eukaryotic protein domain families
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4fa001d5e18b4538b71b32f9cc484470
work_keys_str_mv	AT martajstrumillo conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT michaelaoplova conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT cristinavieitez conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT davidochoa conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT mohammedshahraz conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT bedepbusby conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT richellesopko conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT romainastuder conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT norbertperrimon conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT vikramgpanse conservedphosphorylationhotspotsineukaryoticproteindomainfamilies AT pedrobeltrao conservedphosphorylationhotspotsineukaryoticproteindomainfamilies
_version_	1718386352050929664

Conserved phosphorylation hotspots in eukaryotic protein domain families

Ejemplares similares