Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

The treatment of multiple myeloma is challenging due to high relapse rates. Here the authors show that expression of ADAR1 correlates with poor patient outcomes, and that ADAR1-mediated editing of GLI1 is a mechanism relevant in the context of multiple myeloma progression and drug resistance.

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Autores principales:	Elisa Lazzari, Phoebe K. Mondala, Nathaniel Delos Santos, Amber C. Miller, Gabriel Pineda, Qingfei Jiang, Heather Leu, Shawn A. Ali, Anusha-Preethi Ganesan, Christina N. Wu, Caitlin Costello, Mark Minden, Raffaella Chiaramonte, A. Keith Stewart, Leslie A. Crews, Catriona H. M. Jamieson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4fa1e54ddacc41f0b4c611fc5b44d4d6
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spelling	oai:doaj.org-article:4fa1e54ddacc41f0b4c611fc5b44d4d62021-12-02T14:42:42ZAlu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma10.1038/s41467-017-01890-w2041-1723https://doaj.org/article/4fa1e54ddacc41f0b4c611fc5b44d4d62017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01890-whttps://doaj.org/toc/2041-1723The treatment of multiple myeloma is challenging due to high relapse rates. Here the authors show that expression of ADAR1 correlates with poor patient outcomes, and that ADAR1-mediated editing of GLI1 is a mechanism relevant in the context of multiple myeloma progression and drug resistance.Elisa LazzariPhoebe K. MondalaNathaniel Delos SantosAmber C. MillerGabriel PinedaQingfei JiangHeather LeuShawn A. AliAnusha-Preethi GanesanChristina N. WuCaitlin CostelloMark MindenRaffaella ChiaramonteA. Keith StewartLeslie A. CrewsCatriona H. M. JamiesonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elisa Lazzari Phoebe K. Mondala Nathaniel Delos Santos Amber C. Miller Gabriel Pineda Qingfei Jiang Heather Leu Shawn A. Ali Anusha-Preethi Ganesan Christina N. Wu Caitlin Costello Mark Minden Raffaella Chiaramonte A. Keith Stewart Leslie A. Crews Catriona H. M. Jamieson Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
description	The treatment of multiple myeloma is challenging due to high relapse rates. Here the authors show that expression of ADAR1 correlates with poor patient outcomes, and that ADAR1-mediated editing of GLI1 is a mechanism relevant in the context of multiple myeloma progression and drug resistance.
format	article
author	Elisa Lazzari Phoebe K. Mondala Nathaniel Delos Santos Amber C. Miller Gabriel Pineda Qingfei Jiang Heather Leu Shawn A. Ali Anusha-Preethi Ganesan Christina N. Wu Caitlin Costello Mark Minden Raffaella Chiaramonte A. Keith Stewart Leslie A. Crews Catriona H. M. Jamieson
author_facet	Elisa Lazzari Phoebe K. Mondala Nathaniel Delos Santos Amber C. Miller Gabriel Pineda Qingfei Jiang Heather Leu Shawn A. Ali Anusha-Preethi Ganesan Christina N. Wu Caitlin Costello Mark Minden Raffaella Chiaramonte A. Keith Stewart Leslie A. Crews Catriona H. M. Jamieson
author_sort	Elisa Lazzari
title	Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
title_short	Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
title_full	Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
title_fullStr	Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
title_full_unstemmed	Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
title_sort	alu-dependent rna editing of gli1 promotes malignant regeneration in multiple myeloma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4fa1e54ddacc41f0b4c611fc5b44d4d6
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Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

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