Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer
Alantolactone (ALT) is a natural compound extracted from Chinese traditional medicine Inula helenium L. with therapeutic potential in the treatment of various diseases. Recently, in vitro and in vivo studies have indicated cytotoxic effects of ALT on various cancers, including liver cancer, colorect...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:4fa3911dca374c46ad37a52a5f7c099c2021-12-01T06:59:06ZAlantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer1663-981210.3389/fphar.2021.781033https://doaj.org/article/4fa3911dca374c46ad37a52a5f7c099c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.781033/fullhttps://doaj.org/toc/1663-9812Alantolactone (ALT) is a natural compound extracted from Chinese traditional medicine Inula helenium L. with therapeutic potential in the treatment of various diseases. Recently, in vitro and in vivo studies have indicated cytotoxic effects of ALT on various cancers, including liver cancer, colorectal cancer, breast cancer, etc. The inhibitory effects of ALT depend on several cancer-associated signaling pathways and abnormal regulatory factors in cancer cells. Moreover, emerging studies have reported several promising strategies to enhance the oral bioavailability of ALT, such as combining ALT with other herbs and using ALT-entrapped nanostructured carriers. In this review, studies on the anti-tumor roles of ALT are mainly summarized, and the underlying molecular mechanisms of ALT exerting anticancer effects on cells investigated in animal-based studies are also discussed.Yuan CaiKewa GaoBi PengZhijie XuZhijie XuZhijie XuJinwu PengJinwu PengJuanni LiXi ChenXi ChenShuangshuang ZengShuangshuang ZengKuan HuYuanliang YanFrontiers Media S.A.articleAlantolactoneanticancer effectscancersignaling pathwaysregulatory factorsTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Alantolactone anticancer effects cancer signaling pathways regulatory factors Therapeutics. Pharmacology RM1-950 |
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Alantolactone anticancer effects cancer signaling pathways regulatory factors Therapeutics. Pharmacology RM1-950 Yuan Cai Kewa Gao Bi Peng Zhijie Xu Zhijie Xu Zhijie Xu Jinwu Peng Jinwu Peng Juanni Li Xi Chen Xi Chen Shuangshuang Zeng Shuangshuang Zeng Kuan Hu Yuanliang Yan Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer |
| description |
Alantolactone (ALT) is a natural compound extracted from Chinese traditional medicine Inula helenium L. with therapeutic potential in the treatment of various diseases. Recently, in vitro and in vivo studies have indicated cytotoxic effects of ALT on various cancers, including liver cancer, colorectal cancer, breast cancer, etc. The inhibitory effects of ALT depend on several cancer-associated signaling pathways and abnormal regulatory factors in cancer cells. Moreover, emerging studies have reported several promising strategies to enhance the oral bioavailability of ALT, such as combining ALT with other herbs and using ALT-entrapped nanostructured carriers. In this review, studies on the anti-tumor roles of ALT are mainly summarized, and the underlying molecular mechanisms of ALT exerting anticancer effects on cells investigated in animal-based studies are also discussed. |
| format |
article |
| author |
Yuan Cai Kewa Gao Bi Peng Zhijie Xu Zhijie Xu Zhijie Xu Jinwu Peng Jinwu Peng Juanni Li Xi Chen Xi Chen Shuangshuang Zeng Shuangshuang Zeng Kuan Hu Yuanliang Yan |
| author_facet |
Yuan Cai Kewa Gao Bi Peng Zhijie Xu Zhijie Xu Zhijie Xu Jinwu Peng Jinwu Peng Juanni Li Xi Chen Xi Chen Shuangshuang Zeng Shuangshuang Zeng Kuan Hu Yuanliang Yan |
| author_sort |
Yuan Cai |
| title |
Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer |
| title_short |
Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer |
| title_full |
Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer |
| title_fullStr |
Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer |
| title_full_unstemmed |
Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer |
| title_sort |
alantolactone: a natural plant extract as a potential therapeutic agent for cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/4fa3911dca374c46ad37a52a5f7c099c |
| work_keys_str_mv |
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