Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinica...

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Autores principales:	Sandy Eldridge, Arianna Scuteri, Eugenia M. C. Jones, Guido Cavaletti, Liang Guo, Elizabeth Glaze
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chemotherapy-induced peripheral neuropathy (CIPN) dorsal root ganglion (DRG) peripheral neurons sensory neurons Schwann cells human-induced pluripotent stem cells (hiPSC) Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/4fa4340990ab4ba39a2cd3059c5fe58a
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spelling	oai:doaj.org-article:4fa4340990ab4ba39a2cd3059c5fe58a2021-11-25T19:08:14ZConsiderations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy10.3390/toxics91103002305-6304https://doaj.org/article/4fa4340990ab4ba39a2cd3059c5fe58a2021-11-01T00:00:00Zhttps://www.mdpi.com/2305-6304/9/11/300https://doaj.org/toc/2305-6304Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinical symptoms of CIPN, and the cellular and molecular targets involved in CIPN, are just as diverse as the wide variety of anticancer agents that cause peripheral neurotoxicity. There is an urgent need for extensive molecular and functional investigations aimed at understanding the mechanisms of CIPN. Furthermore, a reliable human cell culture system that recapitulates the diversity of neuronal modalities found in vivo and the pathophysiological changes that underlie CIPN would serve to advance the understanding of the pathogenesis of CIPN. The demonstration of experimental reproducibility in a human peripheral neuronal cell system will increase confidence that such an in vitro model is clinically useful, ultimately resulting in deeper exploration for the prevention and treatment of CIPN. Herein, we review current in vitro models with a focus on key characteristics and attributes desirable for an ideal human cell culture model relevant for CIPN investigations.Sandy EldridgeArianna ScuteriEugenia M. C. JonesGuido CavalettiLiang GuoElizabeth GlazeMDPI AGarticlechemotherapy-induced peripheral neuropathy (CIPN)dorsal root ganglion (DRG)peripheral neuronssensory neuronsSchwann cellshuman-induced pluripotent stem cells (hiPSC)Chemical technologyTP1-1185ENToxics, Vol 9, Iss 300, p 300 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemotherapy-induced peripheral neuropathy (CIPN) dorsal root ganglion (DRG) peripheral neurons sensory neurons Schwann cells human-induced pluripotent stem cells (hiPSC) Chemical technology TP1-1185
spellingShingle	chemotherapy-induced peripheral neuropathy (CIPN) dorsal root ganglion (DRG) peripheral neurons sensory neurons Schwann cells human-induced pluripotent stem cells (hiPSC) Chemical technology TP1-1185 Sandy Eldridge Arianna Scuteri Eugenia M. C. Jones Guido Cavaletti Liang Guo Elizabeth Glaze Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
description	Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinical symptoms of CIPN, and the cellular and molecular targets involved in CIPN, are just as diverse as the wide variety of anticancer agents that cause peripheral neurotoxicity. There is an urgent need for extensive molecular and functional investigations aimed at understanding the mechanisms of CIPN. Furthermore, a reliable human cell culture system that recapitulates the diversity of neuronal modalities found in vivo and the pathophysiological changes that underlie CIPN would serve to advance the understanding of the pathogenesis of CIPN. The demonstration of experimental reproducibility in a human peripheral neuronal cell system will increase confidence that such an in vitro model is clinically useful, ultimately resulting in deeper exploration for the prevention and treatment of CIPN. Herein, we review current in vitro models with a focus on key characteristics and attributes desirable for an ideal human cell culture model relevant for CIPN investigations.
format	article
author	Sandy Eldridge Arianna Scuteri Eugenia M. C. Jones Guido Cavaletti Liang Guo Elizabeth Glaze
author_facet	Sandy Eldridge Arianna Scuteri Eugenia M. C. Jones Guido Cavaletti Liang Guo Elizabeth Glaze
author_sort	Sandy Eldridge
title	Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_short	Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_full	Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_fullStr	Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_full_unstemmed	Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_sort	considerations for a reliable in vitro model of chemotherapy-induced peripheral neuropathy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4fa4340990ab4ba39a2cd3059c5fe58a
work_keys_str_mv	AT sandyeldridge considerationsforareliableinvitromodelofchemotherapyinducedperipheralneuropathy AT ariannascuteri considerationsforareliableinvitromodelofchemotherapyinducedperipheralneuropathy AT eugeniamcjones considerationsforareliableinvitromodelofchemotherapyinducedperipheralneuropathy AT guidocavaletti considerationsforareliableinvitromodelofchemotherapyinducedperipheralneuropathy AT liangguo considerationsforareliableinvitromodelofchemotherapyinducedperipheralneuropathy AT elizabethglaze considerationsforareliableinvitromodelofchemotherapyinducedperipheralneuropathy
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Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy

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