A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.

Simultaneous implementation of magnetic resonance imaging methods for Arterial Spin Labeling (ASL) and Blood Oxygenation Level Dependent (BOLD) imaging makes it possible to quantitatively measure the changes in cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO(2)) that occur in response...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aaron B Simon, Valerie E M Griffeth, Eric C Wong, Richard B Buxton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4fa45635d808435da358e33d9b6c5420
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4fa45635d808435da358e33d9b6c5420
record_format	dspace
spelling	oai:doaj.org-article:4fa45635d808435da358e33d9b6c54202021-11-18T07:59:14ZA novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.1932-620310.1371/journal.pone.0054816https://doaj.org/article/4fa45635d808435da358e33d9b6c54202013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382977/?tool=EBIhttps://doaj.org/toc/1932-6203Simultaneous implementation of magnetic resonance imaging methods for Arterial Spin Labeling (ASL) and Blood Oxygenation Level Dependent (BOLD) imaging makes it possible to quantitatively measure the changes in cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO(2)) that occur in response to neural stimuli. To date, however, the range of neural stimuli amenable to quantitative analysis is limited to those that may be presented in a simple block or event related design such that measurements may be repeated and averaged to improve precision. Here we examined the feasibility of using the relationship between cerebral blood flow and the BOLD signal to improve dynamic estimates of blood flow fluctuations as well as to estimate metabolic-hemodynamic coupling under conditions where a stimulus pattern is unknown. We found that by combining the information contained in simultaneously acquired BOLD and ASL signals through a method we term BOLD Constrained Perfusion (BCP) estimation, we could significantly improve the precision of our estimates of the hemodynamic response to a visual stimulus and, under the conditions of a calibrated BOLD experiment, accurately determine the ratio of the oxygen metabolic response to the hemodynamic response. Importantly we were able to accomplish this without utilizing a priori knowledge of the temporal nature of the neural stimulus, suggesting that BOLD Constrained Perfusion estimation may make it feasible to quantitatively study the cerebral metabolic and hemodynamic responses to more natural stimuli that cannot be easily repeated or averaged.Aaron B SimonValerie E M GriffethEric C WongRichard B BuxtonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54816 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aaron B Simon Valerie E M Griffeth Eric C Wong Richard B Buxton A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
description	Simultaneous implementation of magnetic resonance imaging methods for Arterial Spin Labeling (ASL) and Blood Oxygenation Level Dependent (BOLD) imaging makes it possible to quantitatively measure the changes in cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO(2)) that occur in response to neural stimuli. To date, however, the range of neural stimuli amenable to quantitative analysis is limited to those that may be presented in a simple block or event related design such that measurements may be repeated and averaged to improve precision. Here we examined the feasibility of using the relationship between cerebral blood flow and the BOLD signal to improve dynamic estimates of blood flow fluctuations as well as to estimate metabolic-hemodynamic coupling under conditions where a stimulus pattern is unknown. We found that by combining the information contained in simultaneously acquired BOLD and ASL signals through a method we term BOLD Constrained Perfusion (BCP) estimation, we could significantly improve the precision of our estimates of the hemodynamic response to a visual stimulus and, under the conditions of a calibrated BOLD experiment, accurately determine the ratio of the oxygen metabolic response to the hemodynamic response. Importantly we were able to accomplish this without utilizing a priori knowledge of the temporal nature of the neural stimulus, suggesting that BOLD Constrained Perfusion estimation may make it feasible to quantitatively study the cerebral metabolic and hemodynamic responses to more natural stimuli that cannot be easily repeated or averaged.
format	article
author	Aaron B Simon Valerie E M Griffeth Eric C Wong Richard B Buxton
author_facet	Aaron B Simon Valerie E M Griffeth Eric C Wong Richard B Buxton
author_sort	Aaron B Simon
title	A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
title_short	A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
title_full	A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
title_fullStr	A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
title_full_unstemmed	A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
title_sort	novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4fa45635d808435da358e33d9b6c5420
work_keys_str_mv	AT aaronbsimon anovelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT valerieemgriffeth anovelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT ericcwong anovelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT richardbbuxton anovelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT aaronbsimon novelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT valerieemgriffeth novelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT ericcwong novelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus AT richardbbuxton novelmethodofcombiningbloodoxygenationandbloodflowsensitivemagneticresonanceimagingtechniquestomeasurethecerebralbloodflowandoxygenmetabolismresponsestoanunknownneuralstimulus
_version_	1718422663653752832

A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.

Ejemplares similares