Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber

A compact microfluidic Raman detection system based on a single-ring negative-curvature hollow-core fiber is presented. The system can be used for in-line qualitative and quantitative analysis of biochemicals. Both efficient light coupling and continuous liquid injection into the hollow-core fiber w...

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Autores principales:	Xinyu Wang, Shuguang Li, Shoufei Gao, Yingying Wang, Pu Wang, Heike Ebendorff-Heidepriem, Yinlan Ruan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	negative-curvature fiber Raman scattering fluidic sensing microfluidic cell Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/4fa93125486a46c0a216b6335f261d64
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spelling	oai:doaj.org-article:4fa93125486a46c0a216b6335f261d642021-11-25T16:55:11ZMicrofluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber10.3390/bios111104302079-6374https://doaj.org/article/4fa93125486a46c0a216b6335f261d642021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/430https://doaj.org/toc/2079-6374A compact microfluidic Raman detection system based on a single-ring negative-curvature hollow-core fiber is presented. The system can be used for in-line qualitative and quantitative analysis of biochemicals. Both efficient light coupling and continuous liquid injection into the hollow-core fiber were achieved by creating a small gap between a solid-core fiber and the hollow-core fiber, which were fixed within a low-cost ceramic ferrule. A coupling efficiency of over 50% from free-space excitation laser to the hollow core fiber was obtained through a 350 μm-long solid-core fiber. For proof-of-concept demonstration of bioprocessing monitoring, a series of ethanol and glucose aqueous solutions at different concentrations were used. The limit of detection achieved for the ethanol solutions with our system was ~0.04 vol.% (0.32 g/L). Such an all-fiber microfluidic device is robust, provides Raman measurements with high repeatability and reusability, and is particularly suitable for the in-line monitoring of bioprocesses.Xinyu WangShuguang LiShoufei GaoYingying WangPu WangHeike Ebendorff-HeidepriemYinlan RuanMDPI AGarticlenegative-curvature fiberRaman scatteringfluidic sensingmicrofluidic cellBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 430, p 430 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	negative-curvature fiber Raman scattering fluidic sensing microfluidic cell Biotechnology TP248.13-248.65
spellingShingle	negative-curvature fiber Raman scattering fluidic sensing microfluidic cell Biotechnology TP248.13-248.65 Xinyu Wang Shuguang Li Shoufei Gao Yingying Wang Pu Wang Heike Ebendorff-Heidepriem Yinlan Ruan Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
description	A compact microfluidic Raman detection system based on a single-ring negative-curvature hollow-core fiber is presented. The system can be used for in-line qualitative and quantitative analysis of biochemicals. Both efficient light coupling and continuous liquid injection into the hollow-core fiber were achieved by creating a small gap between a solid-core fiber and the hollow-core fiber, which were fixed within a low-cost ceramic ferrule. A coupling efficiency of over 50% from free-space excitation laser to the hollow core fiber was obtained through a 350 μm-long solid-core fiber. For proof-of-concept demonstration of bioprocessing monitoring, a series of ethanol and glucose aqueous solutions at different concentrations were used. The limit of detection achieved for the ethanol solutions with our system was ~0.04 vol.% (0.32 g/L). Such an all-fiber microfluidic device is robust, provides Raman measurements with high repeatability and reusability, and is particularly suitable for the in-line monitoring of bioprocesses.
format	article
author	Xinyu Wang Shuguang Li Shoufei Gao Yingying Wang Pu Wang Heike Ebendorff-Heidepriem Yinlan Ruan
author_facet	Xinyu Wang Shuguang Li Shoufei Gao Yingying Wang Pu Wang Heike Ebendorff-Heidepriem Yinlan Ruan
author_sort	Xinyu Wang
title	Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
title_short	Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
title_full	Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
title_fullStr	Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
title_full_unstemmed	Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
title_sort	microfluidic raman sensing using a single ring negative curvature hollow core fiber
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4fa93125486a46c0a216b6335f261d64
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Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber

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