$Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi$
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Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi

Elfirta RR, Falah S, Andrianto D, Lastini T. 2018. Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi. Biodiversitas 19: 1313-1318. Inhibitory activities of surian or toon (Toona sinensis) leaves fraction origin Sumedang, West Java, I...

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Autores principales:	RIZKI RABECA ELFIRTA, SYAMSUL FALAH, DIMAS ANDRIANTO, TIEN LASTINI
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2018
Materias:	antifungal surian toona sinensis wood rot fungi Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4fab9142e1b74184b7aa7be49403bed4
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spelling	oai:doaj.org-article:4fab9142e1b74184b7aa7be49403bed42021-11-16T14:03:29ZIdentification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi1412-033X2085-472210.13057/biodiv/d190418https://doaj.org/article/4fab9142e1b74184b7aa7be49403bed42018-07-01T00:00:00Zhttps://smujo.id/biodiv/article/view/2788https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Elfirta RR, Falah S, Andrianto D, Lastini T. 2018. Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi. Biodiversitas 19: 1313-1318. Inhibitory activities of surian or toon (Toona sinensis) leaves fraction origin Sumedang, West Java, Indonesia against wood rot fungi (Ganoderma boninense IPBCC 10.658, Trametes versicolor InaCC F200, and Phanerochaete chrysosporium IPBCC 93.259) were studied. The samples were macerated using methanol and acetone. The results of brine shrimp lethality test (BSLT) showed that the methanol extract had the highest cytotoxicity of LC50 at 29.76 ?g/mL and inhibit the growth of G. boninense (27.78%), T. versicolor (79.26%) and P. chrysosporium (81.11%). The methanol extract was then subsequently fractionated using n-hexane, diethyl ether, and ethyl acetate respectively. The diethyl ether fraction was found to have the highest inhibitory activity against T. versicolor (46.30%) and P. chrysosporium (81.11%). This fraction was further separated using column chromatography and analyzed using thin layer chromatography (TLC), which gave six fractions. Antifungal test exhibited that fraction 5 had the highest antifungal properties against T. versicolor (74.07%) and P. chrysosporium (80.37%). Inhibition of P. chrysosporium resulted in abnormal growth of hyphae morphology as indicated by changes in its growth direction and excessive hyphae branching. Additionally, the results of LC-MS/MS experiment indicated toon leaves fraction 5 which contains N-[2- (D-Glucopyranosyloxy)ethyl]-2-hydroxy-N-[2hydroxy3 (octadecyloxy) propyl] butanamide dan Brucine compounds that were regarded as the antifungal compounds.RIZKI RABECA ELFIRTASYAMSUL FALAHDIMAS ANDRIANTOTIEN LASTINIMBI & UNS Soloarticleantifungalsuriantoona sinensiswood rot fungiBiology (General)QH301-705.5ENBiodiversitas, Vol 19, Iss 4, Pp 1313-1318 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	antifungal surian toona sinensis wood rot fungi Biology (General) QH301-705.5
spellingShingle	antifungal surian toona sinensis wood rot fungi Biology (General) QH301-705.5 RIZKI RABECA ELFIRTA SYAMSUL FALAH DIMAS ANDRIANTO TIEN LASTINI Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi
description	Elfirta RR, Falah S, Andrianto D, Lastini T. 2018. Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi. Biodiversitas 19: 1313-1318. Inhibitory activities of surian or toon (Toona sinensis) leaves fraction origin Sumedang, West Java, Indonesia against wood rot fungi (Ganoderma boninense IPBCC 10.658, Trametes versicolor InaCC F200, and Phanerochaete chrysosporium IPBCC 93.259) were studied. The samples were macerated using methanol and acetone. The results of brine shrimp lethality test (BSLT) showed that the methanol extract had the highest cytotoxicity of LC50 at 29.76 ?g/mL and inhibit the growth of G. boninense (27.78%), T. versicolor (79.26%) and P. chrysosporium (81.11%). The methanol extract was then subsequently fractionated using n-hexane, diethyl ether, and ethyl acetate respectively. The diethyl ether fraction was found to have the highest inhibitory activity against T. versicolor (46.30%) and P. chrysosporium (81.11%). This fraction was further separated using column chromatography and analyzed using thin layer chromatography (TLC), which gave six fractions. Antifungal test exhibited that fraction 5 had the highest antifungal properties against T. versicolor (74.07%) and P. chrysosporium (80.37%). Inhibition of P. chrysosporium resulted in abnormal growth of hyphae morphology as indicated by changes in its growth direction and excessive hyphae branching. Additionally, the results of LC-MS/MS experiment indicated toon leaves fraction 5 which contains N-[2- (D-Glucopyranosyloxy)ethyl]-2-hydroxy-N-[2hydroxy3 (octadecyloxy) propyl] butanamide dan Brucine compounds that were regarded as the antifungal compounds.
format	article
author	RIZKI RABECA ELFIRTA SYAMSUL FALAH DIMAS ANDRIANTO TIEN LASTINI
author_facet	RIZKI RABECA ELFIRTA SYAMSUL FALAH DIMAS ANDRIANTO TIEN LASTINI
author_sort	RIZKI RABECA ELFIRTA
title	Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi
title_short	Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi
title_full	Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi
title_fullStr	Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi
title_full_unstemmed	Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi
title_sort	identification of active compounds and antifungal activity of toona sinensis leaves fractions against wood rot fungi
publisher	MBI & UNS Solo
publishDate	2018
url	https://doaj.org/article/4fab9142e1b74184b7aa7be49403bed4
work_keys_str_mv	AT rizkirabecaelfirta identificationofactivecompoundsandantifungalactivityoftoonasinensisleavesfractionsagainstwoodrotfungi AT syamsulfalah identificationofactivecompoundsandantifungalactivityoftoonasinensisleavesfractionsagainstwoodrotfungi AT dimasandrianto identificationofactivecompoundsandantifungalactivityoftoonasinensisleavesfractionsagainstwoodrotfungi AT tienlastini identificationofactivecompoundsandantifungalactivityoftoonasinensisleavesfractionsagainstwoodrotfungi
_version_	1718426418747015168

Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi

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