Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with hist...

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Autores principales:	Martin Stražar, Godfrey S. Temba, Hera Vlamakis, Vesla I. Kullaya, Furaha Lyamuya, Blandina T. Mmbaga, Leo A. B. Joosten, Andre J. A. M. van der Ven, Mihai G. Netea, Quirijn de Mast, Ramnik J. Xavier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4fabd0c667e74e1cb3314abd5a61efb7
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spelling	oai:doaj.org-article:4fabd0c667e74e1cb3314abd5a61efb72021-12-02T15:07:56ZGut microbiome-mediated metabolism effects on immunity in rural and urban African populations10.1038/s41467-021-25213-22041-1723https://doaj.org/article/4fabd0c667e74e1cb3314abd5a61efb72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25213-2https://doaj.org/toc/2041-1723The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.Martin StražarGodfrey S. TembaHera VlamakisVesla I. KullayaFuraha LyamuyaBlandina T. MmbagaLeo A. B. JoostenAndre J. A. M. van der VenMihai G. NeteaQuirijn de MastRamnik J. XavierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Stražar Godfrey S. Temba Hera Vlamakis Vesla I. Kullaya Furaha Lyamuya Blandina T. Mmbaga Leo A. B. Joosten Andre J. A. M. van der Ven Mihai G. Netea Quirijn de Mast Ramnik J. Xavier Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
description	The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.
format	article
author	Martin Stražar Godfrey S. Temba Hera Vlamakis Vesla I. Kullaya Furaha Lyamuya Blandina T. Mmbaga Leo A. B. Joosten Andre J. A. M. van der Ven Mihai G. Netea Quirijn de Mast Ramnik J. Xavier
author_facet	Martin Stražar Godfrey S. Temba Hera Vlamakis Vesla I. Kullaya Furaha Lyamuya Blandina T. Mmbaga Leo A. B. Joosten Andre J. A. M. van der Ven Mihai G. Netea Quirijn de Mast Ramnik J. Xavier
author_sort	Martin Stražar
title	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_short	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_full	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_fullStr	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_full_unstemmed	Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
title_sort	gut microbiome-mediated metabolism effects on immunity in rural and urban african populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4fabd0c667e74e1cb3314abd5a61efb7
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Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

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