Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.

Although Parkinson disease (PD) causes profound balance impairments, we know very little about how PD impacts the sensorimotor networks we rely on for automatically maintaining balance control. In young healthy people and animals, muscles are activated in a precise temporal and spatial organization...

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Autores principales:	J Lucas McKay, Kimberly C Lang, Sistania M Bong, Madeleine E Hackney, Stewart A Factor, Lena H Ting
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4fadb4a49838447ca9560e7df6eed9c8
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id	oai:doaj.org-article:4fadb4a49838447ca9560e7df6eed9c8
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spelling	oai:doaj.org-article:4fadb4a49838447ca9560e7df6eed9c82021-11-25T06:23:43ZAbnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.1932-620310.1371/journal.pone.0252119https://doaj.org/article/4fadb4a49838447ca9560e7df6eed9c82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252119https://doaj.org/toc/1932-6203Although Parkinson disease (PD) causes profound balance impairments, we know very little about how PD impacts the sensorimotor networks we rely on for automatically maintaining balance control. In young healthy people and animals, muscles are activated in a precise temporal and spatial organization when the center of body mass (CoM) is unexpectedly moved that is largely automatic and determined by feedback of CoM motion. Here, we show that PD alters the sensitivity of the sensorimotor feedback transformation. Importantly, sensorimotor feedback transformations for balance in PD remain temporally precise, but become spatially diffuse by recruiting additional muscle activity in antagonist muscles during balance responses. The abnormal antagonist muscle activity remains precisely time-locked to sensorimotor feedback signals encoding undesirable motion of the body in space. Further, among people with PD, the sensitivity of abnormal antagonist muscle activity to CoM motion varies directly with the number of recent falls. Our work shows that in people with PD, sensorimotor feedback transformations for balance are intact but disinhibited in antagonist muscles, likely contributing to balance deficits and falls.J Lucas McKayKimberly C LangSistania M BongMadeleine E HackneyStewart A FactorLena H TingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252119 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J Lucas McKay Kimberly C Lang Sistania M Bong Madeleine E Hackney Stewart A Factor Lena H Ting Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
description	Although Parkinson disease (PD) causes profound balance impairments, we know very little about how PD impacts the sensorimotor networks we rely on for automatically maintaining balance control. In young healthy people and animals, muscles are activated in a precise temporal and spatial organization when the center of body mass (CoM) is unexpectedly moved that is largely automatic and determined by feedback of CoM motion. Here, we show that PD alters the sensitivity of the sensorimotor feedback transformation. Importantly, sensorimotor feedback transformations for balance in PD remain temporally precise, but become spatially diffuse by recruiting additional muscle activity in antagonist muscles during balance responses. The abnormal antagonist muscle activity remains precisely time-locked to sensorimotor feedback signals encoding undesirable motion of the body in space. Further, among people with PD, the sensitivity of abnormal antagonist muscle activity to CoM motion varies directly with the number of recent falls. Our work shows that in people with PD, sensorimotor feedback transformations for balance are intact but disinhibited in antagonist muscles, likely contributing to balance deficits and falls.
format	article
author	J Lucas McKay Kimberly C Lang Sistania M Bong Madeleine E Hackney Stewart A Factor Lena H Ting
author_facet	J Lucas McKay Kimberly C Lang Sistania M Bong Madeleine E Hackney Stewart A Factor Lena H Ting
author_sort	J Lucas McKay
title	Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
title_short	Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
title_full	Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
title_fullStr	Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
title_full_unstemmed	Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
title_sort	abnormal center of mass feedback responses during balance: a potential biomarker of falls in parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4fadb4a49838447ca9560e7df6eed9c8
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_version_	1718413742376484864

Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.

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