Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite
Jun Hou,1 Donghui Fan,2 Lingming Zhao,2 Baoqin Yu,3 Jiacan Su,3 Jie Wei,2 Jung-Woog Shin4 1The First Affiliated Hospital of Anhui Medical University, Department of Oral and Maxillofacial Surgery, Hefei, 2Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of...
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Dove Medical Press
2016
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oai:doaj.org-article:4fae0cc2970a4562ae0e62235ebfe6052021-12-02T02:01:42ZDegradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite1178-2013https://doaj.org/article/4fae0cc2970a4562ae0e62235ebfe6052016-07-01T00:00:00Zhttps://www.dovepress.com/degradability-cytocompatibility-and-osteogenesis-of-porous-scaffolds-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jun Hou,1 Donghui Fan,2 Lingming Zhao,2 Baoqin Yu,3 Jiacan Su,3 Jie Wei,2 Jung-Woog Shin4 1The First Affiliated Hospital of Anhui Medical University, Department of Oral and Maxillofacial Surgery, Hefei, 2Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 3Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 4Department of Biomedical Engineering, Inje University, Gimhae, Republic of Korea Abstract: Biocomposite scaffolds were fabricated by incorporation of nanobredigite (n-BD) into the polymer of poly(ε-caprolactone)–poly(ethyleneglycol)–poly(ε-caprolactone) (PCL–PEG–PCL). The results revealed that the addition of n-BD into PCL–PEG–PCL significantly improved water absorption, compressive strength, and degradability of the scaffolds of n-BD/PCL–PEG–PCL composite (n-BPC) compared with PCL–PEG–PCL scaffolds alone. In addition, the proliferation and alkaline phosphatase activity of MG63 cells cultured on n-BPC scaffolds were obviously higher than that cultured on PCL–PEG–PCL scaffolds. Moreover, the results of the histological evaluation from the animal model revealed that the n-BPC scaffolds significantly improved new bone formation compared with the PCL–PEG–PCL scaffolds, indicating good osteogenesis. The n-BPC scaffolds with good biocompatibility could stimulate cell proliferation, differentiation, and bone tissue regeneration and would be an excellent candidate for bone defect repair. Keywords: nanobredigite, PCL–PEG–PCL, biocomposite scaffolds, degradability, osteo­genesisHou JFan DHZhao LMYu BQSu JCWei JShin JWDove Medical PressarticlenanobredigitePCL-PEG-PCLbiocomposite scaffoldsdegradabilityosteogenesisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3545-3555 (2016) |
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nanobredigite PCL-PEG-PCL biocomposite scaffolds degradability osteogenesis Medicine (General) R5-920 |
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nanobredigite PCL-PEG-PCL biocomposite scaffolds degradability osteogenesis Medicine (General) R5-920 Hou J Fan DH Zhao LM Yu BQ Su JC Wei J Shin JW Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite |
| description |
Jun Hou,1 Donghui Fan,2 Lingming Zhao,2 Baoqin Yu,3 Jiacan Su,3 Jie Wei,2 Jung-Woog Shin4 1The First Affiliated Hospital of Anhui Medical University, Department of Oral and Maxillofacial Surgery, Hefei, 2Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 3Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 4Department of Biomedical Engineering, Inje University, Gimhae, Republic of Korea Abstract: Biocomposite scaffolds were fabricated by incorporation of nanobredigite (n-BD) into the polymer of poly(ε-caprolactone)–poly(ethyleneglycol)–poly(ε-caprolactone) (PCL–PEG–PCL). The results revealed that the addition of n-BD into PCL–PEG–PCL significantly improved water absorption, compressive strength, and degradability of the scaffolds of n-BD/PCL–PEG–PCL composite (n-BPC) compared with PCL–PEG–PCL scaffolds alone. In addition, the proliferation and alkaline phosphatase activity of MG63 cells cultured on n-BPC scaffolds were obviously higher than that cultured on PCL–PEG–PCL scaffolds. Moreover, the results of the histological evaluation from the animal model revealed that the n-BPC scaffolds significantly improved new bone formation compared with the PCL–PEG–PCL scaffolds, indicating good osteogenesis. The n-BPC scaffolds with good biocompatibility could stimulate cell proliferation, differentiation, and bone tissue regeneration and would be an excellent candidate for bone defect repair. Keywords: nanobredigite, PCL–PEG–PCL, biocomposite scaffolds, degradability, osteo­genesis |
| format |
article |
| author |
Hou J Fan DH Zhao LM Yu BQ Su JC Wei J Shin JW |
| author_facet |
Hou J Fan DH Zhao LM Yu BQ Su JC Wei J Shin JW |
| author_sort |
Hou J |
| title |
Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite |
| title_short |
Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite |
| title_full |
Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite |
| title_fullStr |
Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite |
| title_full_unstemmed |
Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite |
| title_sort |
degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and pcl–peg–pcl composite |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/4fae0cc2970a4562ae0e62235ebfe605 |
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