Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study

Helmuth Haslacher,1 Hannelore Fallmann,2 Claudia Waldhäusl,3 Edith Hartmann,2 Oswald F Wagner,1 Werner K Waldhäusl2,41Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; 2Rehabilitation Clinic for Diabetes and Metabolic Diseases, Moorbad Neydhartig, Ne...

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Autores principales:	Haslacher H, Fallmann H, Waldhäusl C, Hartmann E, Wagner OF, Waldhäusl WK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Obesity standards of care type 2 diabetes liver disease inflammation Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4fafce178f864447b46dcf09397f9ce4
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spelling	oai:doaj.org-article:4fafce178f864447b46dcf09397f9ce42021-12-02T05:28:27ZObesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study1178-7007https://doaj.org/article/4fafce178f864447b46dcf09397f9ce42019-05-01T00:00:00Zhttps://www.dovepress.com/obesity-outcome-of-standardized-life-style-change-in-a-rehabilitation--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Helmuth Haslacher,1 Hannelore Fallmann,2 Claudia Waldhäusl,3 Edith Hartmann,2 Oswald F Wagner,1 Werner K Waldhäusl2,41Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; 2Rehabilitation Clinic for Diabetes and Metabolic Diseases, Moorbad Neydhartig, Neydharting, Upper Austria, Austria; 3Department of Radiotherapy, Medical University of Vienna, Vienna, Austria; 4Department of Medicine III, Medical University of Vienna, Vienna, AustriaPurpose: To explore differences in baseline characteristics following three weeks of semi-standardized in-patient care between patients with obesity without and with type 2 diabetes (T2D).Patients and methods: Patients without or with T2D were matched according to age, sex, and BMI. Food intake was restricted to 1,200–1,600 kcal/d to which a 400–600 kcal/d exercise load was added, and data were compared using Student’s t-test, general linear models, and Spearman-rank correlations.Results: At baseline, patients with obesity and T2D displayed, besides elevated blood glucose and HbA1c values, higher serum liver enzymes (p<0.001–0.05), triglycerides, and CRP (p<0.01) and a greater prevalence of treated hyperlipidemia (p<0.001) than those with plain obesity who showed only higher LDL and HDL cholesterol levels (+9.0% and +16.0%). In response to three-weeks of standardized life-style change, both groups improved their vital variables and risk scores (p<0.001). While improvement in cholesterol slightly favored patients with plain obesity, the need for anti-hyperlipidemics (+25%) rose in both groups, albeit that for anti-hypertensives (+50%) increased only in patients with obesity and add-on T2D.Conclusion: Moderate changes in lifestyle improve the clinical condition, including coronary heart disease and premature mortality risk scores (HARD-CHD and ABSI) in patients with obesity both in the absence and presence of T2D, with the latter seemingly increasing the risk of hepatic steatosis and systemic inflammation.Keywords: obesity, standardized life-style change, liver disease, inflammation, rehabilitation clinic  Haslacher HFallmann HWaldhäusl CHartmann EWagner OFWaldhäusl WKDove Medical PressarticleObesitystandards of caretype 2 diabetesliver diseaseinflammationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 813-820 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity standards of care type 2 diabetes liver disease inflammation Specialties of internal medicine RC581-951
spellingShingle	Obesity standards of care type 2 diabetes liver disease inflammation Specialties of internal medicine RC581-951 Haslacher H Fallmann H Waldhäusl C Hartmann E Wagner OF Waldhäusl WK Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study
description	Helmuth Haslacher,1 Hannelore Fallmann,2 Claudia Waldhäusl,3 Edith Hartmann,2 Oswald F Wagner,1 Werner K Waldhäusl2,41Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; 2Rehabilitation Clinic for Diabetes and Metabolic Diseases, Moorbad Neydhartig, Neydharting, Upper Austria, Austria; 3Department of Radiotherapy, Medical University of Vienna, Vienna, Austria; 4Department of Medicine III, Medical University of Vienna, Vienna, AustriaPurpose: To explore differences in baseline characteristics following three weeks of semi-standardized in-patient care between patients with obesity without and with type 2 diabetes (T2D).Patients and methods: Patients without or with T2D were matched according to age, sex, and BMI. Food intake was restricted to 1,200–1,600 kcal/d to which a 400–600 kcal/d exercise load was added, and data were compared using Student’s t-test, general linear models, and Spearman-rank correlations.Results: At baseline, patients with obesity and T2D displayed, besides elevated blood glucose and HbA1c values, higher serum liver enzymes (p<0.001–0.05), triglycerides, and CRP (p<0.01) and a greater prevalence of treated hyperlipidemia (p<0.001) than those with plain obesity who showed only higher LDL and HDL cholesterol levels (+9.0% and +16.0%). In response to three-weeks of standardized life-style change, both groups improved their vital variables and risk scores (p<0.001). While improvement in cholesterol slightly favored patients with plain obesity, the need for anti-hyperlipidemics (+25%) rose in both groups, albeit that for anti-hypertensives (+50%) increased only in patients with obesity and add-on T2D.Conclusion: Moderate changes in lifestyle improve the clinical condition, including coronary heart disease and premature mortality risk scores (HARD-CHD and ABSI) in patients with obesity both in the absence and presence of T2D, with the latter seemingly increasing the risk of hepatic steatosis and systemic inflammation.Keywords: obesity, standardized life-style change, liver disease, inflammation, rehabilitation clinic
format	article
author	Haslacher H Fallmann H Waldhäusl C Hartmann E Wagner OF Waldhäusl WK
author_facet	Haslacher H Fallmann H Waldhäusl C Hartmann E Wagner OF Waldhäusl WK
author_sort	Haslacher H
title	Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study
title_short	Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study
title_full	Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study
title_fullStr	Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study
title_full_unstemmed	Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study
title_sort	obesity: outcome of standardized life-style change in a rehabilitation clinic. an observational study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4fafce178f864447b46dcf09397f9ce4
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Obesity: outcome of standardized life-style change in a rehabilitation clinic. An observational study

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