Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the...

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Autores principales:	Nestor Mendoza-Muñoz, Zaida Urbán-Morlán, Gerardo Leyva-Gómez, María de la Luz Zambrano-Zaragoza, Elizabeth ¨Piñón-Segundo, David Quintanar-Guerrero
Formato:	article
Lenguaje:	EN
Publicado:	Canadian Society for Pharmaceutical Sciences 2021
Materias:	Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4fb3945c8f974a93b6151974440424d6
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spelling	oai:doaj.org-article:4fb3945c8f974a93b6151974440424d62021-12-02T19:25:28ZSolid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery 10.18433/jpps317881482-1826https://doaj.org/article/4fb3945c8f974a93b6151974440424d62021-10-01T00:00:00Zhttps://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31788https://doaj.org/toc/1482-1826Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the taboo surrounding the complicated transit that this delivery route entails. This review focuses on the encapsulation of drugs into SLN as a strategy for improving oral administration. Examples of applications of SLN to enhance the absorption and bioavailability of poorly-soluble drugs and protect acid-labile active molecules are discussed. This work also emphasizes the importance of developing SLN-based systems to treat health issues such as neurological diseases and cancer, and combat antibiotic resistance, three significant and increasingly common current public health problems. The review sections clarify how SLN can improve bioavailability, target therapeutic agents, and reduce side effects. Nestor Mendoza-MuñozZaida Urbán-MorlánGerardo Leyva-GómezMaría de la Luz Zambrano-ZaragozaElizabeth ¨Piñón-SegundoDavid Quintanar-GuerreroCanadian Society for Pharmaceutical SciencesarticleTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Nestor Mendoza-Muñoz Zaida Urbán-Morlán Gerardo Leyva-Gómez María de la Luz Zambrano-Zaragoza Elizabeth ¨Piñón-Segundo David Quintanar-Guerrero Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
description	Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the taboo surrounding the complicated transit that this delivery route entails. This review focuses on the encapsulation of drugs into SLN as a strategy for improving oral administration. Examples of applications of SLN to enhance the absorption and bioavailability of poorly-soluble drugs and protect acid-labile active molecules are discussed. This work also emphasizes the importance of developing SLN-based systems to treat health issues such as neurological diseases and cancer, and combat antibiotic resistance, three significant and increasingly common current public health problems. The review sections clarify how SLN can improve bioavailability, target therapeutic agents, and reduce side effects.
format	article
author	Nestor Mendoza-Muñoz Zaida Urbán-Morlán Gerardo Leyva-Gómez María de la Luz Zambrano-Zaragoza Elizabeth ¨Piñón-Segundo David Quintanar-Guerrero
author_facet	Nestor Mendoza-Muñoz Zaida Urbán-Morlán Gerardo Leyva-Gómez María de la Luz Zambrano-Zaragoza Elizabeth ¨Piñón-Segundo David Quintanar-Guerrero
author_sort	Nestor Mendoza-Muñoz
title	Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
title_short	Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
title_full	Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
title_fullStr	Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
title_full_unstemmed	Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
title_sort	solid lipid nanoparticles: an approach to improve oral drug delivery
publisher	Canadian Society for Pharmaceutical Sciences
publishDate	2021
url	https://doaj.org/article/4fb3945c8f974a93b6151974440424d6
work_keys_str_mv	AT nestormendozamunoz solidlipidnanoparticlesanapproachtoimproveoraldrugdelivery AT zaidaurbanmorlan solidlipidnanoparticlesanapproachtoimproveoraldrugdelivery AT gerardoleyvagomez solidlipidnanoparticlesanapproachtoimproveoraldrugdelivery AT mariadelaluzzambranozaragoza solidlipidnanoparticlesanapproachtoimproveoraldrugdelivery AT elizabethpinonsegundo solidlipidnanoparticlesanapproachtoimproveoraldrugdelivery AT davidquintanarguerrero solidlipidnanoparticlesanapproachtoimproveoraldrugdelivery
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Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

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