Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System

The central nervous system (CNS) is highly compartmentalized and serves as a specific site of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular populations that are infected by HIV or that harbor latent HIV proviruses is imperative in the attempts to address c...

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Autores principales:	Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Priya Tyagi, Alok Bhushan, Mudit Tyagi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV transcriptional regulation latency therapy central nervous system Medicine R
Acceso en línea:	https://doaj.org/article/4fb52a8409f74b18b4d04eb47c5caf09
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spelling	oai:doaj.org-article:4fb52a8409f74b18b4d04eb47c5caf092021-11-25T19:10:49ZHuman Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System10.3390/vaccines91112722076-393Xhttps://doaj.org/article/4fb52a8409f74b18b4d04eb47c5caf092021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1272https://doaj.org/toc/2076-393XThe central nervous system (CNS) is highly compartmentalized and serves as a specific site of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular populations that are infected by HIV or that harbor latent HIV proviruses is imperative in the attempts to address cure strategies, taking into account that HIV infection and latency in the CNS may differ considerably from those in the periphery. HIV replication in the CNS is reported to persist despite prolonged combination antiretroviral therapy due to the inability of the current antiretroviral drugs to penetrate and cross the blood–brain barrier. Consequently, as a result of sustained HIV replication in the CNS even in the face of combination antiretroviral therapy, there is a high incidence of HIV-associated neurocognitive disorders (HAND). This article, therefore, provides a comprehensive review of HIV transcriptional regulation, latency, and therapy in the CNS.Joseph HokelloAdhikarimayum Lakhikumar SharmaPriya TyagiAlok BhushanMudit TyagiMDPI AGarticleHIVtranscriptional regulationlatencytherapycentral nervous systemMedicineRENVaccines, Vol 9, Iss 1272, p 1272 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV transcriptional regulation latency therapy central nervous system Medicine R
spellingShingle	HIV transcriptional regulation latency therapy central nervous system Medicine R Joseph Hokello Adhikarimayum Lakhikumar Sharma Priya Tyagi Alok Bhushan Mudit Tyagi Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System
description	The central nervous system (CNS) is highly compartmentalized and serves as a specific site of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular populations that are infected by HIV or that harbor latent HIV proviruses is imperative in the attempts to address cure strategies, taking into account that HIV infection and latency in the CNS may differ considerably from those in the periphery. HIV replication in the CNS is reported to persist despite prolonged combination antiretroviral therapy due to the inability of the current antiretroviral drugs to penetrate and cross the blood–brain barrier. Consequently, as a result of sustained HIV replication in the CNS even in the face of combination antiretroviral therapy, there is a high incidence of HIV-associated neurocognitive disorders (HAND). This article, therefore, provides a comprehensive review of HIV transcriptional regulation, latency, and therapy in the CNS.
format	article
author	Joseph Hokello Adhikarimayum Lakhikumar Sharma Priya Tyagi Alok Bhushan Mudit Tyagi
author_facet	Joseph Hokello Adhikarimayum Lakhikumar Sharma Priya Tyagi Alok Bhushan Mudit Tyagi
author_sort	Joseph Hokello
title	Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System
title_short	Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System
title_full	Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System
title_fullStr	Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System
title_full_unstemmed	Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System
title_sort	human immunodeficiency virus type-1 (hiv-1) transcriptional regulation, latency and therapy in the central nervous system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4fb52a8409f74b18b4d04eb47c5caf09
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Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System

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