Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet

Alcohol is metabolized in liver. Chronic alcohol abuse results in alcohol-induced fatty liver and liver injury. Red quinoa (<i>Chenopodium formosanum</i>) was a traditional staple food for Taiwanese aborigines. Red quinoa bran (RQB) included strong anti-oxidative and anti-inflammatory po...

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Autores principales:	Ting-An Lin, Bo-Jun Ke, Shih-Cheng Cheng, Chun-Lin Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Chenopodium formosanum</i> red quinoa bran alcoholic liver disease red quinoa extraction process rutin Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/4fb5817c77ed4447815160553ba5495c
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spelling	oai:doaj.org-article:4fb5817c77ed4447815160553ba5495c2021-11-25T18:28:50ZRed Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet10.3390/molecules262269731420-3049https://doaj.org/article/4fb5817c77ed4447815160553ba5495c2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6973https://doaj.org/toc/1420-3049Alcohol is metabolized in liver. Chronic alcohol abuse results in alcohol-induced fatty liver and liver injury. Red quinoa (<i>Chenopodium formosanum</i>) was a traditional staple food for Taiwanese aborigines. Red quinoa bran (RQB) included strong anti-oxidative and anti-inflammatory polyphenolic compounds, but it was usually regarded as the agricultural waste. Therefore, this study is to investigate the effect of water and ethanol extraction products of RQB on the prevention of liquid alcoholic diet-induced acute liver injury in mice. The mice were given whole grain powder of red quinoa (RQ-P), RQB ethanol extract (RQB-E), RQB water extract (RQB-W), and rutin orally for 6 weeks, respectively. The results indicated that RQB-E, RQB-W, and rutin decreased alcoholic diet-induced activities of aspartate aminotransferase and alanine aminotransferase, and the levels of serum triglyceride, total cholesterol, and hepatic triglyceride. Hematoxylin and eosin staining of liver tissues showed that RQB-E and RQB-W reduced lipid droplet accumulation and liver injury. However, ethanol extraction process can gain high rutin and antioxidative agents contents from red quinoa, that showed strong effects in preventing alcoholic fatty liver disease and liver injury via increasing superoxide dismutase/catalase antioxidative system and repressing the expressions of fatty acid synthesis enzyme acetyl-CoA carboxylase.Ting-An LinBo-Jun KeShih-Cheng ChengChun-Lin LeeMDPI AGarticle<i>Chenopodium formosanum</i>red quinoa branalcoholic liver diseasered quinoa extraction processrutinOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6973, p 6973 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Chenopodium formosanum</i> red quinoa bran alcoholic liver disease red quinoa extraction process rutin Organic chemistry QD241-441
spellingShingle	<i>Chenopodium formosanum</i> red quinoa bran alcoholic liver disease red quinoa extraction process rutin Organic chemistry QD241-441 Ting-An Lin Bo-Jun Ke Shih-Cheng Cheng Chun-Lin Lee Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet
description	Alcohol is metabolized in liver. Chronic alcohol abuse results in alcohol-induced fatty liver and liver injury. Red quinoa (<i>Chenopodium formosanum</i>) was a traditional staple food for Taiwanese aborigines. Red quinoa bran (RQB) included strong anti-oxidative and anti-inflammatory polyphenolic compounds, but it was usually regarded as the agricultural waste. Therefore, this study is to investigate the effect of water and ethanol extraction products of RQB on the prevention of liquid alcoholic diet-induced acute liver injury in mice. The mice were given whole grain powder of red quinoa (RQ-P), RQB ethanol extract (RQB-E), RQB water extract (RQB-W), and rutin orally for 6 weeks, respectively. The results indicated that RQB-E, RQB-W, and rutin decreased alcoholic diet-induced activities of aspartate aminotransferase and alanine aminotransferase, and the levels of serum triglyceride, total cholesterol, and hepatic triglyceride. Hematoxylin and eosin staining of liver tissues showed that RQB-E and RQB-W reduced lipid droplet accumulation and liver injury. However, ethanol extraction process can gain high rutin and antioxidative agents contents from red quinoa, that showed strong effects in preventing alcoholic fatty liver disease and liver injury via increasing superoxide dismutase/catalase antioxidative system and repressing the expressions of fatty acid synthesis enzyme acetyl-CoA carboxylase.
format	article
author	Ting-An Lin Bo-Jun Ke Shih-Cheng Cheng Chun-Lin Lee
author_facet	Ting-An Lin Bo-Jun Ke Shih-Cheng Cheng Chun-Lin Lee
author_sort	Ting-An Lin
title	Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet
title_short	Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet
title_full	Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet
title_fullStr	Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet
title_full_unstemmed	Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet
title_sort	red quinoa bran extract prevented alcoholic fatty liver disease via increasing antioxidative system and repressing fatty acid synthesis factors in mice fed alcohol liquid diet
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4fb5817c77ed4447815160553ba5495c
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Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet

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