Inflammatory cytokines and atrial fibrillation: current and prospective views

Hadi AR Hadi, Alawi A Alsheikh-Ali, Wael AL Mahmeed, Jassim M Al SuwaidiInstitute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab EmiratesAbstract: Atrial fibrillation (AF) is the most common sustained arrhythmia and a &shy;challenging clinical problem encountered in...

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Autores principales:	Hadi AR Hadi, Alawi A Alsheikh-Ali, Wael AL Mahmeed, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4fb916e35a2b432d876397a0b85788d1
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spelling	oai:doaj.org-article:4fb916e35a2b432d876397a0b85788d12021-12-02T00:44:14ZInflammatory cytokines and atrial fibrillation: current and prospective views1178-7031https://doaj.org/article/4fb916e35a2b432d876397a0b85788d12010-08-01T00:00:00Zhttp://www.dovepress.com/inflammatory-cytokines-and-atrial-fibrillation-current-and-prospective-a5155https://doaj.org/toc/1178-7031Hadi AR Hadi, Alawi A Alsheikh-Ali, Wael AL Mahmeed, Jassim M Al SuwaidiInstitute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab EmiratesAbstract: Atrial fibrillation (AF) is the most common sustained arrhythmia and a &shy;challenging clinical problem encountered in daily clinical practice. There is an increasing body of evidence linking inflammation to a broad spectrum of cardiovascular conditions including AF. Historical evidence supports an association between AF and inflammation and is consistent with the association of AF with inflammatory conditions of the heart, such as myocarditis and pericarditis. AF has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. Increased plasma interleukin (IL)-6, C-reactive protein (CRP), and plasma viscosity support the existence of an inflammatory state among &ldquo;typical&rdquo; populations with chronic AF. These indexes of inflammation are related to the prothrombotic state and may be linked to the clinical characteristics of the patients (underlying vascular disease and comorbidities), rather than simply to the presence of AF itself. It has been suggested that inflammation may have a role in the development of atrial arrhythmias after cardiac surgery, and that a genetic predisposition to develop postoperative complications exists. Cytokines can have a prognostic significance; IL-6 levels, CRP, and other cytokines may have prognostic value in AF. Cytokine lowering therapies, statins, angiotensin converting enzyme inhibitors and other anti-inflammatory agents may have a role in the treatment of AF. The present article provides an overview of the evidence linking inflammatory cytokines to AF and their therapeutic and prognostic implications.Keywords: atrial fibrillation, inflammation, cytokines Hadi AR HadiAlawi A Alsheikh-AliWael AL Mahmeedet al.Dove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2010, Iss default, Pp 75-97 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Hadi AR Hadi Alawi A Alsheikh-Ali Wael AL Mahmeed et al. Inflammatory cytokines and atrial fibrillation: current and prospective views
description	Hadi AR Hadi, Alawi A Alsheikh-Ali, Wael AL Mahmeed, Jassim M Al SuwaidiInstitute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab EmiratesAbstract: Atrial fibrillation (AF) is the most common sustained arrhythmia and a &shy;challenging clinical problem encountered in daily clinical practice. There is an increasing body of evidence linking inflammation to a broad spectrum of cardiovascular conditions including AF. Historical evidence supports an association between AF and inflammation and is consistent with the association of AF with inflammatory conditions of the heart, such as myocarditis and pericarditis. AF has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. Increased plasma interleukin (IL)-6, C-reactive protein (CRP), and plasma viscosity support the existence of an inflammatory state among &ldquo;typical&rdquo; populations with chronic AF. These indexes of inflammation are related to the prothrombotic state and may be linked to the clinical characteristics of the patients (underlying vascular disease and comorbidities), rather than simply to the presence of AF itself. It has been suggested that inflammation may have a role in the development of atrial arrhythmias after cardiac surgery, and that a genetic predisposition to develop postoperative complications exists. Cytokines can have a prognostic significance; IL-6 levels, CRP, and other cytokines may have prognostic value in AF. Cytokine lowering therapies, statins, angiotensin converting enzyme inhibitors and other anti-inflammatory agents may have a role in the treatment of AF. The present article provides an overview of the evidence linking inflammatory cytokines to AF and their therapeutic and prognostic implications.Keywords: atrial fibrillation, inflammation, cytokines
format	article
author	Hadi AR Hadi Alawi A Alsheikh-Ali Wael AL Mahmeed et al.
author_facet	Hadi AR Hadi Alawi A Alsheikh-Ali Wael AL Mahmeed et al.
author_sort	Hadi AR Hadi
title	Inflammatory cytokines and atrial fibrillation: current and prospective views
title_short	Inflammatory cytokines and atrial fibrillation: current and prospective views
title_full	Inflammatory cytokines and atrial fibrillation: current and prospective views
title_fullStr	Inflammatory cytokines and atrial fibrillation: current and prospective views
title_full_unstemmed	Inflammatory cytokines and atrial fibrillation: current and prospective views
title_sort	inflammatory cytokines and atrial fibrillation: current and prospective views
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/4fb916e35a2b432d876397a0b85788d1
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Inflammatory cytokines and atrial fibrillation: current and prospective views

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