Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice

Abstract Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. Traumatic stress during adolescence increases the risk of IBS in adults. The aim of this study was to characterize the juvenile social defeat stress (SDS)-associated IBS model in mice. Juvenile mice were...

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Autores principales:	Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh, Shinichi Kato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4fb9e575fcde4cd0be3226169baa42ca
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spelling	oai:doaj.org-article:4fb9e575fcde4cd0be3226169baa42ca2021-12-02T18:50:47ZJuvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice10.1038/s41598-021-95916-52045-2322https://doaj.org/article/4fb9e575fcde4cd0be3226169baa42ca2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95916-5https://doaj.org/toc/2045-2322Abstract Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. Traumatic stress during adolescence increases the risk of IBS in adults. The aim of this study was to characterize the juvenile social defeat stress (SDS)-associated IBS model in mice. Juvenile mice were exposed to an aggressor mouse for 10 min once daily for 10 consecutive days. Behavioral tests, visceral sensitivity, immune responses, and fecal bacteria in the colon were evaluated in 5 weeks after SDS exposure. Social avoidance, anxiety- and depression-like behavior, and visceral hypersensitivity were observed. Juvenile SDS exposure significantly increased the number of 5-HT-containing cells and calcitonin gene-related peptide-positive neurons in the colon. The gut microbiota was largely similar between the control and juvenile SDS groups. The alterations in fecal pellet output, bead expulsion time, plasma corticosterone concentration, and colonic 5-HT content in response to restraint stress were exacerbated in the juvenile SDS group compared with the control group. The combination of juvenile SDS and restraint stress increased the noradrenaline metabolite 3-Methoxy-4-hydroxyphenylglycol (MHPG) content and MHPG/noradrenaline ratio in the amygdala when compared with restraint stress in control mice. These results suggest that juvenile SDS exposure results in later onset of IBS-like symptoms.Kenjiro MatsumotoKana TakataDaisuke YamadaHaruki UsudaKoichiro WadaMaaya TadaYoshiyuki MishimaShunji IshiharaSyunji HorieAkiyoshi SaitohShinichi KatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenjiro Matsumoto Kana Takata Daisuke Yamada Haruki Usuda Koichiro Wada Maaya Tada Yoshiyuki Mishima Shunji Ishihara Syunji Horie Akiyoshi Saitoh Shinichi Kato Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
description	Abstract Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. Traumatic stress during adolescence increases the risk of IBS in adults. The aim of this study was to characterize the juvenile social defeat stress (SDS)-associated IBS model in mice. Juvenile mice were exposed to an aggressor mouse for 10 min once daily for 10 consecutive days. Behavioral tests, visceral sensitivity, immune responses, and fecal bacteria in the colon were evaluated in 5 weeks after SDS exposure. Social avoidance, anxiety- and depression-like behavior, and visceral hypersensitivity were observed. Juvenile SDS exposure significantly increased the number of 5-HT-containing cells and calcitonin gene-related peptide-positive neurons in the colon. The gut microbiota was largely similar between the control and juvenile SDS groups. The alterations in fecal pellet output, bead expulsion time, plasma corticosterone concentration, and colonic 5-HT content in response to restraint stress were exacerbated in the juvenile SDS group compared with the control group. The combination of juvenile SDS and restraint stress increased the noradrenaline metabolite 3-Methoxy-4-hydroxyphenylglycol (MHPG) content and MHPG/noradrenaline ratio in the amygdala when compared with restraint stress in control mice. These results suggest that juvenile SDS exposure results in later onset of IBS-like symptoms.
format	article
author	Kenjiro Matsumoto Kana Takata Daisuke Yamada Haruki Usuda Koichiro Wada Maaya Tada Yoshiyuki Mishima Shunji Ishihara Syunji Horie Akiyoshi Saitoh Shinichi Kato
author_facet	Kenjiro Matsumoto Kana Takata Daisuke Yamada Haruki Usuda Koichiro Wada Maaya Tada Yoshiyuki Mishima Shunji Ishihara Syunji Horie Akiyoshi Saitoh Shinichi Kato
author_sort	Kenjiro Matsumoto
title	Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
title_short	Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
title_full	Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
title_fullStr	Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
title_full_unstemmed	Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
title_sort	juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4fb9e575fcde4cd0be3226169baa42ca
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Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice

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