Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disorder mediated by excessive autoantibodies. Here the authors show that an E3 ubiquitin ligase, Peli1, negatively modulates noncanonical NF-κB signaling to restrain lupus-like symptoms in mice, and that Peli1 expression inversely correlates with...

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Autores principales:	Junli Liu, Xinfang Huang, Shumeng Hao, Yan Wang, Manman Liu, Jing Xu, Xingli Zhang, Tao Yu, Shucheng Gan, Dongfang Dai, Xuan Luo, Qingyan Lu, Chaoming Mao, Yanyun Zhang, Nan Shen, Bin Li, Mingzhu Huang, Xiaodong Zhu, Jin Jin, Xuhong Cheng, Shao-Cong Sun, Yichuan Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4fbc1cbd1c0b4fbbae8a8e223f91514a
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spelling	oai:doaj.org-article:4fbc1cbd1c0b4fbbae8a8e223f91514a2021-12-02T16:49:37ZPeli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus10.1038/s41467-018-03530-32041-1723https://doaj.org/article/4fbc1cbd1c0b4fbbae8a8e223f91514a2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03530-3https://doaj.org/toc/2041-1723Systemic lupus erythematosus (SLE) is an autoimmune disorder mediated by excessive autoantibodies. Here the authors show that an E3 ubiquitin ligase, Peli1, negatively modulates noncanonical NF-κB signaling to restrain lupus-like symptoms in mice, and that Peli1 expression inversely correlates with SLE severity in humans.Junli LiuXinfang HuangShumeng HaoYan WangManman LiuJing XuXingli ZhangTao YuShucheng GanDongfang DaiXuan LuoQingyan LuChaoming MaoYanyun ZhangNan ShenBin LiMingzhu HuangXiaodong ZhuJin JinXuhong ChengShao-Cong SunYichuan XiaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junli Liu Xinfang Huang Shumeng Hao Yan Wang Manman Liu Jing Xu Xingli Zhang Tao Yu Shucheng Gan Dongfang Dai Xuan Luo Qingyan Lu Chaoming Mao Yanyun Zhang Nan Shen Bin Li Mingzhu Huang Xiaodong Zhu Jin Jin Xuhong Cheng Shao-Cong Sun Yichuan Xiao Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
description	Systemic lupus erythematosus (SLE) is an autoimmune disorder mediated by excessive autoantibodies. Here the authors show that an E3 ubiquitin ligase, Peli1, negatively modulates noncanonical NF-κB signaling to restrain lupus-like symptoms in mice, and that Peli1 expression inversely correlates with SLE severity in humans.
format	article
author	Junli Liu Xinfang Huang Shumeng Hao Yan Wang Manman Liu Jing Xu Xingli Zhang Tao Yu Shucheng Gan Dongfang Dai Xuan Luo Qingyan Lu Chaoming Mao Yanyun Zhang Nan Shen Bin Li Mingzhu Huang Xiaodong Zhu Jin Jin Xuhong Cheng Shao-Cong Sun Yichuan Xiao
author_facet	Junli Liu Xinfang Huang Shumeng Hao Yan Wang Manman Liu Jing Xu Xingli Zhang Tao Yu Shucheng Gan Dongfang Dai Xuan Luo Qingyan Lu Chaoming Mao Yanyun Zhang Nan Shen Bin Li Mingzhu Huang Xiaodong Zhu Jin Jin Xuhong Cheng Shao-Cong Sun Yichuan Xiao
author_sort	Junli Liu
title	Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
title_short	Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
title_full	Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
title_fullStr	Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
title_full_unstemmed	Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
title_sort	peli1 negatively regulates noncanonical nf-κb signaling to restrain systemic lupus erythematosus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4fbc1cbd1c0b4fbbae8a8e223f91514a
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Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus

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