THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS

The inflammatory bronchopulmonary diseases are relevant public health problem. The general characteristics of this diseases group are significant proportion of patients that does not react properly on ongoing antibiotic therapy. The reason may be various disorders of the immune system. It is known t...

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Autores principales:	E. S. Korovkina, S. V. Kazharova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	community-acquired pneumonia adaptive immunity innate immunity dendritic cells toll-like receptors pathogen-associated molecular patterns mutations of toll-like receptors polymorphism of toll-like receptors antimicrobial therapeutic vaccine Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/4fbce344b0ef447184e69485488f6f07
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spelling	oai:doaj.org-article:4fbce344b0ef447184e69485488f6f072021-11-22T07:09:47ZTHE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS2220-76192313-739810.15789/2220-7619-2016-2-109-116https://doaj.org/article/4fbce344b0ef447184e69485488f6f072016-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/396https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The inflammatory bronchopulmonary diseases are relevant public health problem. The general characteristics of this diseases group are significant proportion of patients that does not react properly on ongoing antibiotic therapy. The reason may be various disorders of the immune system. It is known that the development of immune response to pathogen involves a complex interaction of cells and molecules of innate and adaptive immune systems. Currently dendritic cells are considered as a connecting link between innate and adaptive immunity. Toll-like receptors function and expression are intensively investigated in norm and in pathology last decade, which are the most important members of the family of signaling receptors and play an important role in the activation of mechanisms of innate immunity. Infection is one of the major factors that influence in the expression of the toll-like receptors. The level of expression directly correlates with the severity of the process. In some cases toll-like receptors allows as early markers of infection. Consider the role of the toll-like receptors in the development of normal immune response, coudn’t exclude the various defects in signal transmission systems and in the receptors structure in patients with inflammatory diseases. That is why defining the role of toll-like receptors in various diseases is advisable and in the future will allow to improve the effectiveness of the therapy. Nowadays have not generally accepted effective methods of the inflammatory bronchopulmonary diseases immunocorrection, there also remains the problem of prevention and therapy. In particular, discuss the use of immunomodulators, so called “therapeutic vaccines” that have the ability to stimulate the antigen-specific response.E. S. KorovkinaS. V. KazharovaSankt-Peterburg : NIIÈM imeni Pasteraarticlecommunity-acquired pneumoniaadaptive immunityinnate immunitydendritic cellstoll-like receptorspathogen-associated molecular patternsmutations of toll-like receptorspolymorphism of toll-like receptorsantimicrobial therapeutic vaccineInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 2, Pp 109-116 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	community-acquired pneumonia adaptive immunity innate immunity dendritic cells toll-like receptors pathogen-associated molecular patterns mutations of toll-like receptors polymorphism of toll-like receptors antimicrobial therapeutic vaccine Infectious and parasitic diseases RC109-216
spellingShingle	community-acquired pneumonia adaptive immunity innate immunity dendritic cells toll-like receptors pathogen-associated molecular patterns mutations of toll-like receptors polymorphism of toll-like receptors antimicrobial therapeutic vaccine Infectious and parasitic diseases RC109-216 E. S. Korovkina S. V. Kazharova THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS
description	The inflammatory bronchopulmonary diseases are relevant public health problem. The general characteristics of this diseases group are significant proportion of patients that does not react properly on ongoing antibiotic therapy. The reason may be various disorders of the immune system. It is known that the development of immune response to pathogen involves a complex interaction of cells and molecules of innate and adaptive immune systems. Currently dendritic cells are considered as a connecting link between innate and adaptive immunity. Toll-like receptors function and expression are intensively investigated in norm and in pathology last decade, which are the most important members of the family of signaling receptors and play an important role in the activation of mechanisms of innate immunity. Infection is one of the major factors that influence in the expression of the toll-like receptors. The level of expression directly correlates with the severity of the process. In some cases toll-like receptors allows as early markers of infection. Consider the role of the toll-like receptors in the development of normal immune response, coudn’t exclude the various defects in signal transmission systems and in the receptors structure in patients with inflammatory diseases. That is why defining the role of toll-like receptors in various diseases is advisable and in the future will allow to improve the effectiveness of the therapy. Nowadays have not generally accepted effective methods of the inflammatory bronchopulmonary diseases immunocorrection, there also remains the problem of prevention and therapy. In particular, discuss the use of immunomodulators, so called “therapeutic vaccines” that have the ability to stimulate the antigen-specific response.
format	article
author	E. S. Korovkina S. V. Kazharova
author_facet	E. S. Korovkina S. V. Kazharova
author_sort	E. S. Korovkina
title	THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS
title_short	THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS
title_full	THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS
title_fullStr	THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS
title_full_unstemmed	THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS
title_sort	toll-like receptors role in inflammatory diseases of the bronchopulmonary system pathogenesis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/4fbce344b0ef447184e69485488f6f07
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THE TOLL-LIKE RECEPTORS ROLE IN INFLAMMATORY DISEASES OF THE BRONCHOPULMONARY SYSTEM PATHOGENESIS

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