Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction
The miR-17-92 cluster has been shown to regulate cardiomyocyte proliferation in vitro and in genetic mutation and overexpression models. Here the authors show that the cluster member miR-19a/19b regulates cardiomyocyte proliferation in vivo, and that delivery of miR-19a/19b to the heart leads to bot...
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Nature Portfolio
2019
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oai:doaj.org-article:4fc1b6c932d84c21b2b0cc9b87242fbc2021-12-02T17:01:51ZTherapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction10.1038/s41467-019-09530-12041-1723https://doaj.org/article/4fc1b6c932d84c21b2b0cc9b87242fbc2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09530-1https://doaj.org/toc/2041-1723The miR-17-92 cluster has been shown to regulate cardiomyocyte proliferation in vitro and in genetic mutation and overexpression models. Here the authors show that the cluster member miR-19a/19b regulates cardiomyocyte proliferation in vivo, and that delivery of miR-19a/19b to the heart leads to both short-term and long-term protective responses to myocardial infarction.Feng GaoMasaharu KataokaNing LiuTian LiangZhan-Peng HuangFei GuJian DingJianming LiuFeng ZhangQing MaYingchao WangMingming ZhangXiaoyun HuJan KyselovicXinyang HuWilliam T. PuJian’an WangJinghai ChenDa-Zhi WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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| spellingShingle |
Science Q Feng Gao Masaharu Kataoka Ning Liu Tian Liang Zhan-Peng Huang Fei Gu Jian Ding Jianming Liu Feng Zhang Qing Ma Yingchao Wang Mingming Zhang Xiaoyun Hu Jan Kyselovic Xinyang Hu William T. Pu Jian’an Wang Jinghai Chen Da-Zhi Wang Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction |
| description |
The miR-17-92 cluster has been shown to regulate cardiomyocyte proliferation in vitro and in genetic mutation and overexpression models. Here the authors show that the cluster member miR-19a/19b regulates cardiomyocyte proliferation in vivo, and that delivery of miR-19a/19b to the heart leads to both short-term and long-term protective responses to myocardial infarction. |
| format |
article |
| author |
Feng Gao Masaharu Kataoka Ning Liu Tian Liang Zhan-Peng Huang Fei Gu Jian Ding Jianming Liu Feng Zhang Qing Ma Yingchao Wang Mingming Zhang Xiaoyun Hu Jan Kyselovic Xinyang Hu William T. Pu Jian’an Wang Jinghai Chen Da-Zhi Wang |
| author_facet |
Feng Gao Masaharu Kataoka Ning Liu Tian Liang Zhan-Peng Huang Fei Gu Jian Ding Jianming Liu Feng Zhang Qing Ma Yingchao Wang Mingming Zhang Xiaoyun Hu Jan Kyselovic Xinyang Hu William T. Pu Jian’an Wang Jinghai Chen Da-Zhi Wang |
| author_sort |
Feng Gao |
| title |
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction |
| title_short |
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction |
| title_full |
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction |
| title_fullStr |
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction |
| title_full_unstemmed |
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction |
| title_sort |
therapeutic role of mir-19a/19b in cardiac regeneration and protection from myocardial infarction |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4fc1b6c932d84c21b2b0cc9b87242fbc |
| work_keys_str_mv |
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1718382027981455360 |