Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.

Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) have been implicated as important players during demyelination in both animal models of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gerry Z M Ma, Jim Stankovich, Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Trevor J Kilpatrick, Michele D Binder, Judith Field
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4fc7f388196f48d39cbfd9d636a89161
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4fc7f388196f48d39cbfd9d636a89161
record_format	dspace
spelling	oai:doaj.org-article:4fc7f388196f48d39cbfd9d636a891612021-11-18T06:59:06ZPolymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.1932-620310.1371/journal.pone.0016964https://doaj.org/article/4fc7f388196f48d39cbfd9d636a891612011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21347448/?tool=EBIhttps://doaj.org/toc/1932-6203Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) have been implicated as important players during demyelination in both animal models of MS and in the human disease. We therefore conducted an association study to identify single nucleotide polymorphisms (SNPs) within genes encoding the TAM receptors and their ligands associated with MS. Analysis of genotype data from a genome-wide association study which consisted of 1618 MS cases and 3413 healthy controls conducted by the Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) revealed several SNPs within the MERTK gene (Chromosome 2q14.1, Accession Number NG_011607.1) that showed suggestive association with MS. We therefore interrogated 28 SNPs in MERTK in an independent replication cohort of 1140 MS cases and 1140 healthy controls. We found 12 SNPs that replicated, with 7 SNPs showing p-values of less than 10(-5) when the discovery and replication cohorts were combined. All 12 replicated SNPs were in strong linkage disequilibrium with each other. In combination, these data suggest the MERTK gene is a novel risk gene for MS susceptibility.Gerry Z M MaJim StankovichAustralia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene)Trevor J KilpatrickMichele D BinderJudith FieldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e16964 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gerry Z M Ma Jim Stankovich Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) Trevor J Kilpatrick Michele D Binder Judith Field Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.
description	Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) have been implicated as important players during demyelination in both animal models of MS and in the human disease. We therefore conducted an association study to identify single nucleotide polymorphisms (SNPs) within genes encoding the TAM receptors and their ligands associated with MS. Analysis of genotype data from a genome-wide association study which consisted of 1618 MS cases and 3413 healthy controls conducted by the Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) revealed several SNPs within the MERTK gene (Chromosome 2q14.1, Accession Number NG_011607.1) that showed suggestive association with MS. We therefore interrogated 28 SNPs in MERTK in an independent replication cohort of 1140 MS cases and 1140 healthy controls. We found 12 SNPs that replicated, with 7 SNPs showing p-values of less than 10(-5) when the discovery and replication cohorts were combined. All 12 replicated SNPs were in strong linkage disequilibrium with each other. In combination, these data suggest the MERTK gene is a novel risk gene for MS susceptibility.
format	article
author	Gerry Z M Ma Jim Stankovich Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) Trevor J Kilpatrick Michele D Binder Judith Field
author_facet	Gerry Z M Ma Jim Stankovich Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) Trevor J Kilpatrick Michele D Binder Judith Field
author_sort	Gerry Z M Ma
title	Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.
title_short	Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.
title_full	Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.
title_fullStr	Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.
title_full_unstemmed	Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.
title_sort	polymorphisms in the receptor tyrosine kinase mertk gene are associated with multiple sclerosis susceptibility.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4fc7f388196f48d39cbfd9d636a89161
work_keys_str_mv	AT gerryzmma polymorphismsinthereceptortyrosinekinasemertkgeneareassociatedwithmultiplesclerosissusceptibility AT jimstankovich polymorphismsinthereceptortyrosinekinasemertkgeneareassociatedwithmultiplesclerosissusceptibility AT australiaandnewzealandmultiplesclerosisgeneticsconsortiumanzgene polymorphismsinthereceptortyrosinekinasemertkgeneareassociatedwithmultiplesclerosissusceptibility AT trevorjkilpatrick polymorphismsinthereceptortyrosinekinasemertkgeneareassociatedwithmultiplesclerosissusceptibility AT micheledbinder polymorphismsinthereceptortyrosinekinasemertkgeneareassociatedwithmultiplesclerosissusceptibility AT judithfield polymorphismsinthereceptortyrosinekinasemertkgeneareassociatedwithmultiplesclerosissusceptibility
_version_	1718424102128058368

Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.

Ejemplares similares