Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis

Abstract Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the progression and metastasis of several different...

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Autores principales:	Huey-En Tzeng, Syuan-Ling Lin, Louis Anoop Thadevoos, Ming-Yu Lien, Wei-Hung Yang, Chih-Yuan Ko, Chih-Yang Lin, Yu-Wen Huang, Ju-Fang Liu, Yi-Chin Fong, Hsien-Te Chen, Chih-Hsin Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/4fcab6fdf7e64a368c815ac2f97733f3
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spelling	oai:doaj.org-article:4fcab6fdf7e64a368c815ac2f97733f32021-11-28T12:04:30ZNerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis10.1038/s41419-021-04392-22041-4889https://doaj.org/article/4fcab6fdf7e64a368c815ac2f97733f32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41419-021-04392-2https://doaj.org/toc/2041-4889Abstract Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the progression and metastasis of several different types of tumors, although the effects of NGF upon chondrosarcoma mechanisms are not very clear. We report that NGF facilitates lysyl oxidase (LOX)-dependent cellular migration and invasion in human chondrosarcoma cells, and that NGF overexpression enhances lung metastasis in a mouse model of chondrosarcoma. NGF-induced stimulation of LOX production and cell motility occurs through the inhibition of miR-149-5p expression, which was reversed by PI3K, Akt, and mTOR inhibitors and their respective short interfering RNAs. Notably, levels of NGF and LOX expression correlated with tumor stage in human chondrosarcoma samples. Thus, NGF appears to be a worthwhile therapeutic target for metastatic chondrosarcoma.Huey-En TzengSyuan-Ling LinLouis Anoop ThadevoosMing-Yu LienWei-Hung YangChih-Yuan KoChih-Yang LinYu-Wen HuangJu-Fang LiuYi-Chin FongHsien-Te ChenChih-Hsin TangNature Publishing GrouparticleCytologyQH573-671ENCell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Huey-En Tzeng Syuan-Ling Lin Louis Anoop Thadevoos Ming-Yu Lien Wei-Hung Yang Chih-Yuan Ko Chih-Yang Lin Yu-Wen Huang Ju-Fang Liu Yi-Chin Fong Hsien-Te Chen Chih-Hsin Tang Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
description	Abstract Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the progression and metastasis of several different types of tumors, although the effects of NGF upon chondrosarcoma mechanisms are not very clear. We report that NGF facilitates lysyl oxidase (LOX)-dependent cellular migration and invasion in human chondrosarcoma cells, and that NGF overexpression enhances lung metastasis in a mouse model of chondrosarcoma. NGF-induced stimulation of LOX production and cell motility occurs through the inhibition of miR-149-5p expression, which was reversed by PI3K, Akt, and mTOR inhibitors and their respective short interfering RNAs. Notably, levels of NGF and LOX expression correlated with tumor stage in human chondrosarcoma samples. Thus, NGF appears to be a worthwhile therapeutic target for metastatic chondrosarcoma.
format	article
author	Huey-En Tzeng Syuan-Ling Lin Louis Anoop Thadevoos Ming-Yu Lien Wei-Hung Yang Chih-Yuan Ko Chih-Yang Lin Yu-Wen Huang Ju-Fang Liu Yi-Chin Fong Hsien-Te Chen Chih-Hsin Tang
author_facet	Huey-En Tzeng Syuan-Ling Lin Louis Anoop Thadevoos Ming-Yu Lien Wei-Hung Yang Chih-Yuan Ko Chih-Yang Lin Yu-Wen Huang Ju-Fang Liu Yi-Chin Fong Hsien-Te Chen Chih-Hsin Tang
author_sort	Huey-En Tzeng
title	Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
title_short	Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
title_full	Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
title_fullStr	Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
title_full_unstemmed	Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
title_sort	nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing mir-149-5p synthesis
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/4fcab6fdf7e64a368c815ac2f97733f3
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Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis

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