Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant <i>Mycobacterium tuberculosis</i> Isolates in China
As the causative bacteria of tuberculosis, <i>Mycobacterium</i><i>tuberculosis (M. tb</i><i>)</i> is aggravated by the emergence of its multidrug-resistant isolates in China. Mutations of six of the most frequently reported resistant genes (<i>rpoB, katG, in...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4fcd90176046498484c3b51853f06eb8 |
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| Sumario: | As the causative bacteria of tuberculosis, <i>Mycobacterium</i><i>tuberculosis (M. tb</i><i>)</i> is aggravated by the emergence of its multidrug-resistant isolates in China. Mutations of six of the most frequently reported resistant genes (<i>rpoB, katG, inhA, embB, gyrA,</i> and <i>rpsL</i>) were detected for rifampicin (RIF), isoniazid (INH), ethambutol (EMB), ofloxacin (OFX), and streptomycin (STR) in this study. The amino acid missense mutations (MMs) and their corresponding single nucleotide polymorphism mutations for all drug-resistant (DR) isolates are described in detail. All isolates were divided into non-extensively drug-resistant (Non-XDR) and preXDR/XDR groups. No statistical differences were detected among MMs and linked MMs (LMs) between the two groups, except for <i>rpsL</i> 88 (<i>p</i> = 0.037). In the preXDR/XDR group, the occurrence of MMs in <i>rpoB, katG,</i> and <i>inhA</i> developed phenotypic resistance and MMs of <i>rpoB</i> 531, <i>katG</i> 315, <i>rpsL</i> 43, and <i>rpsL</i> 88 could develop high levels of DR. It is necessary to carry out epidemiological investigations of DR gene mutations in the local region, and thus provide necessary data to support the design of new technologies for rapid detection of resistant <i>M. tb</i> and the optimization of detection targets. |
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