A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker

A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker

Background: Metastasis-Associated in Colon Cancer 1(<i>MACC1</i>) is a validated biomarker for metastasis and is linked to survival. Although extensive experimental evidence indicates an association between <i>MACC1</i> and diverse cancers, no pan-cancer analyses have yet be...

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Autores principales: Ye Hu, Meiling Wang, Kainan Wang, Jiyue Gao, Jiaci Tong, Zuowei Zhao, Man Li
Formato: article
Lenguaje:EN
Publicado: AIMS Press 2021
Materias:
<i>macc1</i>
pan-cancer analysis
cancer immunology
biomarkers
Biotechnology
TP248.13-248.65
Mathematics
QA1-939
Acceso en línea:https://doaj.org/article/4fd2072c5b2744bc87a561d506433d97
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spelling oai:doaj.org-article:4fd2072c5b2744bc87a561d506433d972021-11-24T01:18:47ZA potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker10.3934/mbe.20214131551-0018https://doaj.org/article/4fd2072c5b2744bc87a561d506433d972021-09-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021413?viewType=HTMLhttps://doaj.org/toc/1551-0018Background: Metastasis-Associated in Colon Cancer 1(<i>MACC1</i>) is a validated biomarker for metastasis and is linked to survival. Although extensive experimental evidence indicates an association between <i>MACC1</i> and diverse cancers, no pan-cancer analyses have yet been performed for this marker, and the role of <i>MACC1</i> in immunology remains unknown. Material and Methods: In our study, we performed the analysis of <i>MACC1</i> expression and its influence on prognosis using multiple databases, including TIMER2, GEPIA2, Kaplan-Meier plotter. <i>MACC1</i> promoter methylation levels were evaluated using the UALCAN database. Based on the TCGA database, we explored the relationship between <i>MACC1</i> and tumor mutational burden (TMB), microsatellite instability (MSI), immune checkpoints using the R programming language. We evaluated the association between <i>MACC1</i> and immune infiltration via TIMER and UALCAN. Results: Our results revealed that abnormal DNA methylation may be an important cause for the different expression of <i>MACC1</i> across cancer types. Meanwhile, we explored the potential oncogenic roles of <i>MACC1</i> and found significant prognostic value. <i>MACC1</i> may be related to T-cell function and the polarization of tumor-associated macrophages, especially in STAD and LGG. Its expression was associated with immune infiltration and was found to be closely related to immune checkpoint-associated genes, especially CD274 and SIGLEC15, indicating that <i>MACC1</i> may be a potential immune therapeutic target for several malignancies. Our paper reveals for the first time the relationship between <i>MACC1</i> and cancer immunology. Conclusions: <i>MACC1</i> might act as a predictor for the immune response in cancer patients, and could also represent a new potential immunotherapeutic target.Ye HuMeiling Wang Kainan Wang Jiyue GaoJiaci TongZuowei ZhaoMan LiAIMS Pressarticle<i>macc1</i>pan-cancer analysiscancer immunologybiomarkersBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 8331-8353 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>macc1</i>
pan-cancer analysis
cancer immunology
biomarkers
Biotechnology
TP248.13-248.65
Mathematics
QA1-939
spellingShingle <i>macc1</i>
pan-cancer analysis
cancer immunology
biomarkers
Biotechnology
TP248.13-248.65
Mathematics
QA1-939
Ye Hu
Meiling Wang
Kainan Wang
Jiyue Gao
Jiaci Tong
Zuowei Zhao
Man Li
A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
description Background: Metastasis-Associated in Colon Cancer 1(<i>MACC1</i>) is a validated biomarker for metastasis and is linked to survival. Although extensive experimental evidence indicates an association between <i>MACC1</i> and diverse cancers, no pan-cancer analyses have yet been performed for this marker, and the role of <i>MACC1</i> in immunology remains unknown. Material and Methods: In our study, we performed the analysis of <i>MACC1</i> expression and its influence on prognosis using multiple databases, including TIMER2, GEPIA2, Kaplan-Meier plotter. <i>MACC1</i> promoter methylation levels were evaluated using the UALCAN database. Based on the TCGA database, we explored the relationship between <i>MACC1</i> and tumor mutational burden (TMB), microsatellite instability (MSI), immune checkpoints using the R programming language. We evaluated the association between <i>MACC1</i> and immune infiltration via TIMER and UALCAN. Results: Our results revealed that abnormal DNA methylation may be an important cause for the different expression of <i>MACC1</i> across cancer types. Meanwhile, we explored the potential oncogenic roles of <i>MACC1</i> and found significant prognostic value. <i>MACC1</i> may be related to T-cell function and the polarization of tumor-associated macrophages, especially in STAD and LGG. Its expression was associated with immune infiltration and was found to be closely related to immune checkpoint-associated genes, especially CD274 and SIGLEC15, indicating that <i>MACC1</i> may be a potential immune therapeutic target for several malignancies. Our paper reveals for the first time the relationship between <i>MACC1</i> and cancer immunology. Conclusions: <i>MACC1</i> might act as a predictor for the immune response in cancer patients, and could also represent a new potential immunotherapeutic target.
format article
author Ye Hu
Meiling Wang
Kainan Wang
Jiyue Gao
Jiaci Tong
Zuowei Zhao
Man Li
author_facet Ye Hu
Meiling Wang
Kainan Wang
Jiyue Gao
Jiaci Tong
Zuowei Zhao
Man Li
author_sort Ye Hu
title A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
title_short A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
title_full A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
title_fullStr A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
title_full_unstemmed A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
title_sort potential role for metastasis-associated in colon cancer 1 (<i>macc1</i>) as a pan-cancer prognostic and immunological biomarker
publisher AIMS Press
publishDate 2021
url https://doaj.org/article/4fd2072c5b2744bc87a561d506433d97
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