On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women

Background: The prevalence of varicose veins of small pelvic veins in women of reproductive age varies widely – from 5.4 to 80 %, due to the low specificity and low sensitivity of clinical diagnostic techniques, and the absence of biomarkers that can be used to identify the formation and progression...

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Autores principales:	L. I. Kolesnikova, A. A. Semendyaev, D. A. Stupin, M. A. Darenskaya, L. A. Grebenkina, L. V. Natyaganova, A. N. Kalyagin, A V. Shcherbatykh, A. A. Petukhov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	varicose veins of small pelvis in women lipid peroxidation antioxidant enzymes biological markers Science Q
Acceso en línea:	https://doaj.org/article/4fda8be6068541f59002b872f887d105
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spelling	oai:doaj.org-article:4fda8be6068541f59002b872f887d1052021-11-23T06:14:43ZOn the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women2541-94202587-959610.29413/ABS.2020-5.1.2https://doaj.org/article/4fda8be6068541f59002b872f887d1052020-03-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2234https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background: The prevalence of varicose veins of small pelvic veins in women of reproductive age varies widely – from 5.4 to 80 %, due to the low specificity and low sensitivity of clinical diagnostic techniques, and the absence of biomarkers that can be used to identify the formation and progression of varicose veins of small pelvic veins in women.Aims: To identify changes in the levels of parameters of the system “lipid peroxidation – antioxidant protection” with the development of varicose veins of the pelvis in women, as well as the possibility of their diagnostic use.Materials and methods: We examined 200 women with clinical signs of varicose veins of small pelvis. Control group included 30 women without any pathology of venous system. Treatment group included 137 women with varicose veins of small pelvis: with mild degree of severity – 39 women, with moderate degree of severity – 65 women, with severe degree of severity – 33 women. We performed comparative analysis of lipid peroxidation – antioxidant defense system in women with and without varicose veins of small pelvis taking into account the severity degrees of pathological process.Results: We obtained the most informative indices for lipid peroxidation – antioxidant defense processes in blood of women with varicose veins of small pelvis: concentration of diene conjugate (DC) for the mild degree of severity of pathological process, lipid hydroperoxide (LHP), DC and malonic dialdehyde (MDA) – for the moderate and severe degree of severity, and also changes in the activity of antioxidant enzymes with increase of the severity of the disease. Assessment of the level of catalase (Cat) and glutathione peroxidase (GP) showed their highest informative value at the mild degree of severity. Concentrations of glutathione reductase (GR), glutathione S-transferase (GST) and reduced glutathione (GSH) are more statistically significant markers for severe forms of pathological process.Conclusions: Our research showed the relevance and advisability of the studying the levels of lipid peroxidation – antioxidant defense indices in women with varicose veins of small pelvis. We registered the highest diagnostic value of DC, Cat and GP in the beginning of the disease and of LHP, DC, MDA, GR, GST and GSH – at severe forms of the pathological process. We obtained reference values for DC, MDA, Cat, SOD and GP concentration that can be considered as the predictors of the development of varicose veins of small pelvis.L. I. KolesnikovaA. A. SemendyaevD. A. StupinM. A. DarenskayaL. A. GrebenkinaL. V. NatyaganovaA. N. KalyaginA V. ShcherbatykhA. A. PetukhovScientific Сentre for Family Health and Human Reproduction Problemsarticlevaricose veins of small pelvis in womenlipid peroxidationantioxidant enzymesbiological markersScienceQRUActa Biomedica Scientifica, Vol 5, Iss 1, Pp 14-20 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	varicose veins of small pelvis in women lipid peroxidation antioxidant enzymes biological markers Science Q
spellingShingle	varicose veins of small pelvis in women lipid peroxidation antioxidant enzymes biological markers Science Q L. I. Kolesnikova A. A. Semendyaev D. A. Stupin M. A. Darenskaya L. A. Grebenkina L. V. Natyaganova A. N. Kalyagin A V. Shcherbatykh A. A. Petukhov On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
description	Background: The prevalence of varicose veins of small pelvic veins in women of reproductive age varies widely – from 5.4 to 80 %, due to the low specificity and low sensitivity of clinical diagnostic techniques, and the absence of biomarkers that can be used to identify the formation and progression of varicose veins of small pelvic veins in women.Aims: To identify changes in the levels of parameters of the system “lipid peroxidation – antioxidant protection” with the development of varicose veins of the pelvis in women, as well as the possibility of their diagnostic use.Materials and methods: We examined 200 women with clinical signs of varicose veins of small pelvis. Control group included 30 women without any pathology of venous system. Treatment group included 137 women with varicose veins of small pelvis: with mild degree of severity – 39 women, with moderate degree of severity – 65 women, with severe degree of severity – 33 women. We performed comparative analysis of lipid peroxidation – antioxidant defense system in women with and without varicose veins of small pelvis taking into account the severity degrees of pathological process.Results: We obtained the most informative indices for lipid peroxidation – antioxidant defense processes in blood of women with varicose veins of small pelvis: concentration of diene conjugate (DC) for the mild degree of severity of pathological process, lipid hydroperoxide (LHP), DC and malonic dialdehyde (MDA) – for the moderate and severe degree of severity, and also changes in the activity of antioxidant enzymes with increase of the severity of the disease. Assessment of the level of catalase (Cat) and glutathione peroxidase (GP) showed their highest informative value at the mild degree of severity. Concentrations of glutathione reductase (GR), glutathione S-transferase (GST) and reduced glutathione (GSH) are more statistically significant markers for severe forms of pathological process.Conclusions: Our research showed the relevance and advisability of the studying the levels of lipid peroxidation – antioxidant defense indices in women with varicose veins of small pelvis. We registered the highest diagnostic value of DC, Cat and GP in the beginning of the disease and of LHP, DC, MDA, GR, GST and GSH – at severe forms of the pathological process. We obtained reference values for DC, MDA, Cat, SOD and GP concentration that can be considered as the predictors of the development of varicose veins of small pelvis.
format	article
author	L. I. Kolesnikova A. A. Semendyaev D. A. Stupin M. A. Darenskaya L. A. Grebenkina L. V. Natyaganova A. N. Kalyagin A V. Shcherbatykh A. A. Petukhov
author_facet	L. I. Kolesnikova A. A. Semendyaev D. A. Stupin M. A. Darenskaya L. A. Grebenkina L. V. Natyaganova A. N. Kalyagin A V. Shcherbatykh A. A. Petukhov
author_sort	L. I. Kolesnikova
title	On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
title_short	On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
title_full	On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
title_fullStr	On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
title_full_unstemmed	On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
title_sort	on the opportunities of using the indices of lipid peroxidation – antioxidant defense system in the diagnostics of varicose veins of small pelvis in women
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/4fda8be6068541f59002b872f887d105
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On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women

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