Heart Rate Variability in Insulo-Opercular Epilepsy

Background: We aimed to evaluate heart rate variability (HRV) changes in insulo-opercular epilepsy (IOE) and after insulo-opercular surgery. Methods: We analyzed 5-min resting HRV of IOE patients before and after surgery. Patients’ SUDEP-7 risk inventory scores were also calculated. Results were com...

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Autores principales:	Thi Phuoc Yen Tran, Philippe Pouliot, Elie Bou Assi, Pierre Rainville, Kenneth A. Myers, Manon Robert, Alain Bouthillier, Mark R. Keezer, Dang Khoa Nguyen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heart rate variability insulo-opercular epilepsy cardiac autonomic dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/4fdc4f2e143d40c8bd42ff77b115af3c
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spelling	oai:doaj.org-article:4fdc4f2e143d40c8bd42ff77b115af3c2021-11-25T16:58:38ZHeart Rate Variability in Insulo-Opercular Epilepsy10.3390/brainsci111115052076-3425https://doaj.org/article/4fdc4f2e143d40c8bd42ff77b115af3c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1505https://doaj.org/toc/2076-3425Background: We aimed to evaluate heart rate variability (HRV) changes in insulo-opercular epilepsy (IOE) and after insulo-opercular surgery. Methods: We analyzed 5-min resting HRV of IOE patients before and after surgery. Patients’ SUDEP-7 risk inventory scores were also calculated. Results were compared with age- and sex-matched patients with temporal lobe epilepsy (TLE) and healthy individuals. Results: There were no differences in HRV measurements between IOE, TLE, and healthy control groups (and within each IOE group and TLE group) in preoperative and postoperative periods. In IOE patients, the SUDEP-7 score was positively correlated with pNN50 (percentage of successive RR intervals that differ by more than 50 ms) (<i>p</i> = 0.008) and RMSSD (root mean square of successive RR interval differences) (<i>p</i> = 0.019). We stratified IOE patients into those whose preoperative RMSSD values were below (Group 1a = 7) versus above (Group 1b = 9) a cut-off threshold of 31 ms (median value of a healthy population from a previous study). In group 1a, all HRV values significantly increased after surgery. In group 1b, time-domain parameters significantly decreased postoperatively. Conclusions: Our results suggest that in IOE, HRV may be either decreased in parasympathetic tone or increased globally in both sympathetic and parasympathetic tones. We found no evidence that insulo-opercular surgeries lead to major autonomic dysfunction when a good seizure outcome is reached. The increase in parasympathetic tone observed preoperatively may be of clinical concern, as it was positively correlated with the SUDEP-7 score.Thi Phuoc Yen TranPhilippe PouliotElie Bou AssiPierre RainvilleKenneth A. MyersManon RobertAlain BouthillierMark R. KeezerDang Khoa NguyenMDPI AGarticleheart rate variabilityinsulo-opercular epilepsycardiac autonomic dysfunctionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1505, p 1505 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart rate variability insulo-opercular epilepsy cardiac autonomic dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	heart rate variability insulo-opercular epilepsy cardiac autonomic dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Thi Phuoc Yen Tran Philippe Pouliot Elie Bou Assi Pierre Rainville Kenneth A. Myers Manon Robert Alain Bouthillier Mark R. Keezer Dang Khoa Nguyen Heart Rate Variability in Insulo-Opercular Epilepsy
description	Background: We aimed to evaluate heart rate variability (HRV) changes in insulo-opercular epilepsy (IOE) and after insulo-opercular surgery. Methods: We analyzed 5-min resting HRV of IOE patients before and after surgery. Patients’ SUDEP-7 risk inventory scores were also calculated. Results were compared with age- and sex-matched patients with temporal lobe epilepsy (TLE) and healthy individuals. Results: There were no differences in HRV measurements between IOE, TLE, and healthy control groups (and within each IOE group and TLE group) in preoperative and postoperative periods. In IOE patients, the SUDEP-7 score was positively correlated with pNN50 (percentage of successive RR intervals that differ by more than 50 ms) (<i>p</i> = 0.008) and RMSSD (root mean square of successive RR interval differences) (<i>p</i> = 0.019). We stratified IOE patients into those whose preoperative RMSSD values were below (Group 1a = 7) versus above (Group 1b = 9) a cut-off threshold of 31 ms (median value of a healthy population from a previous study). In group 1a, all HRV values significantly increased after surgery. In group 1b, time-domain parameters significantly decreased postoperatively. Conclusions: Our results suggest that in IOE, HRV may be either decreased in parasympathetic tone or increased globally in both sympathetic and parasympathetic tones. We found no evidence that insulo-opercular surgeries lead to major autonomic dysfunction when a good seizure outcome is reached. The increase in parasympathetic tone observed preoperatively may be of clinical concern, as it was positively correlated with the SUDEP-7 score.
format	article
author	Thi Phuoc Yen Tran Philippe Pouliot Elie Bou Assi Pierre Rainville Kenneth A. Myers Manon Robert Alain Bouthillier Mark R. Keezer Dang Khoa Nguyen
author_facet	Thi Phuoc Yen Tran Philippe Pouliot Elie Bou Assi Pierre Rainville Kenneth A. Myers Manon Robert Alain Bouthillier Mark R. Keezer Dang Khoa Nguyen
author_sort	Thi Phuoc Yen Tran
title	Heart Rate Variability in Insulo-Opercular Epilepsy
title_short	Heart Rate Variability in Insulo-Opercular Epilepsy
title_full	Heart Rate Variability in Insulo-Opercular Epilepsy
title_fullStr	Heart Rate Variability in Insulo-Opercular Epilepsy
title_full_unstemmed	Heart Rate Variability in Insulo-Opercular Epilepsy
title_sort	heart rate variability in insulo-opercular epilepsy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4fdc4f2e143d40c8bd42ff77b115af3c
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Heart Rate Variability in Insulo-Opercular Epilepsy

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