Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry

Background. Concurrent evidence about cardiogenic shock (CS) characteristics, treatment and outcome does not represent a global spectrum of patients and is therefore limited. The aim of this study was to investigate these regional differences. Methods. To investigate regional differences in presenta...

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Autores principales:	Michal Pazdernik, Mario Gramegna, Allan Bohm, Maria Trepa, Christophe Vandenbriele, Salvatore De Rosa, Jamol Uzokov, Milica Aleksic, Milana Jarakovic, Mohammad El Tahlawi, Morsy Mostafa, Maria Stratinaki, Diego Araiza-Garaygordobil, Ekaterina Gubareva, Polina Duplyakova, Manuel Chacon-Diaz, Hesham Refaat, Federico Guerra, Alberto Maria Cappelletti, Vojtech Berka, Dirk Westermann, Benedikt Schrage
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	kew words: cardiogenic shock regional differences mechanical circulatory support acute heart failure amics Medicine R
Acceso en línea:	https://doaj.org/article/4fe278ca854e4e1a91040e5e0e4fbfcb
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spelling	oai:doaj.org-article:4fe278ca854e4e1a91040e5e0e4fbfcb2021-11-29T08:47:12ZRegional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry1213-81181804-752110.5507/bp.2021.046https://doaj.org/article/4fe278ca854e4e1a91040e5e0e4fbfcb2021-09-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202103-0009_regional-differences-in-presentation-characteristics-use-of-treatments-and-outcome-of-patients-with-cardiogeni.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Background. Concurrent evidence about cardiogenic shock (CS) characteristics, treatment and outcome does not represent a global spectrum of patients and is therefore limited. The aim of this study was to investigate these regional differences. Methods. To investigate regional differences in presentation characteristics, treatments and outcomes of patients treated with all types of cardiogenic shock (CS) in a single calendar year on a multi-national level. Consecutive patients from 19 tertiary care hospitals in 13 countries with CS who were treated between January 1, 2018 and December 31, 2018 were enrolled in this study. Results. In total, 699 cardiogenic shock patients were included in this study. Of these patients, 440 patients (63%) were treated in European hospitals and 259 (37%) were treated in Non-European hospitals. Female patients (P<0.01) and patients with a previous myocardial infarction (P=0.02) were more likely to present at Non-European hospitals; whereas older patients (P=0.01) and patients with cardiogenic shock due to acute heart failure (P<0.01) were more likely to present at European hospitals. Vasopressor use was more likely in Non-European hospitals (P=0.04), whereas use of mechanical circulatory support (MCS) was more likely in European hospitals (P<0.01). Despite adjustment for relevant confounders, 30-day in-hospital mortality risk was comparably high in CS patients treated in European vs. Non-European hospitals (hazard ratio 1.08, 95% CI 0.84-1.39, P=0.56). Conclusion. Despite marked heterogeneity in characteristics and treatment of CS patients, including fewer use of MCS but more frequent use of vasopressors in Non-European hospitals, 30-day in-hospital mortality did not differ between regions.Michal PazdernikMario GramegnaAllan BohmMaria TrepaChristophe VandenbrieleSalvatore De RosaJamol UzokovMilica AleksicMilana JarakovicMohammad El TahlawiMorsy MostafaMaria StratinakiDiego Araiza-GaraygordobilEkaterina GubarevaPolina DuplyakovaManuel Chacon-DiazHesham RefaatFederico GuerraAlberto Maria CappellettiVojtech BerkaDirk WestermannBenedikt SchragePalacký University Olomouc, Faculty of Medicine and Dentistryarticlekew words: cardiogenic shockregional differencesmechanical circulatory supportacute heart failureamicsMedicineRENBiomedical Papers, Vol 165, Iss 3, Pp 291-297 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	kew words: cardiogenic shock regional differences mechanical circulatory support acute heart failure amics Medicine R
spellingShingle	kew words: cardiogenic shock regional differences mechanical circulatory support acute heart failure amics Medicine R Michal Pazdernik Mario Gramegna Allan Bohm Maria Trepa Christophe Vandenbriele Salvatore De Rosa Jamol Uzokov Milica Aleksic Milana Jarakovic Mohammad El Tahlawi Morsy Mostafa Maria Stratinaki Diego Araiza-Garaygordobil Ekaterina Gubareva Polina Duplyakova Manuel Chacon-Diaz Hesham Refaat Federico Guerra Alberto Maria Cappelletti Vojtech Berka Dirk Westermann Benedikt Schrage Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
description	Background. Concurrent evidence about cardiogenic shock (CS) characteristics, treatment and outcome does not represent a global spectrum of patients and is therefore limited. The aim of this study was to investigate these regional differences. Methods. To investigate regional differences in presentation characteristics, treatments and outcomes of patients treated with all types of cardiogenic shock (CS) in a single calendar year on a multi-national level. Consecutive patients from 19 tertiary care hospitals in 13 countries with CS who were treated between January 1, 2018 and December 31, 2018 were enrolled in this study. Results. In total, 699 cardiogenic shock patients were included in this study. Of these patients, 440 patients (63%) were treated in European hospitals and 259 (37%) were treated in Non-European hospitals. Female patients (P<0.01) and patients with a previous myocardial infarction (P=0.02) were more likely to present at Non-European hospitals; whereas older patients (P=0.01) and patients with cardiogenic shock due to acute heart failure (P<0.01) were more likely to present at European hospitals. Vasopressor use was more likely in Non-European hospitals (P=0.04), whereas use of mechanical circulatory support (MCS) was more likely in European hospitals (P<0.01). Despite adjustment for relevant confounders, 30-day in-hospital mortality risk was comparably high in CS patients treated in European vs. Non-European hospitals (hazard ratio 1.08, 95% CI 0.84-1.39, P=0.56). Conclusion. Despite marked heterogeneity in characteristics and treatment of CS patients, including fewer use of MCS but more frequent use of vasopressors in Non-European hospitals, 30-day in-hospital mortality did not differ between regions.
format	article
author	Michal Pazdernik Mario Gramegna Allan Bohm Maria Trepa Christophe Vandenbriele Salvatore De Rosa Jamol Uzokov Milica Aleksic Milana Jarakovic Mohammad El Tahlawi Morsy Mostafa Maria Stratinaki Diego Araiza-Garaygordobil Ekaterina Gubareva Polina Duplyakova Manuel Chacon-Diaz Hesham Refaat Federico Guerra Alberto Maria Cappelletti Vojtech Berka Dirk Westermann Benedikt Schrage
author_facet	Michal Pazdernik Mario Gramegna Allan Bohm Maria Trepa Christophe Vandenbriele Salvatore De Rosa Jamol Uzokov Milica Aleksic Milana Jarakovic Mohammad El Tahlawi Morsy Mostafa Maria Stratinaki Diego Araiza-Garaygordobil Ekaterina Gubareva Polina Duplyakova Manuel Chacon-Diaz Hesham Refaat Federico Guerra Alberto Maria Cappelletti Vojtech Berka Dirk Westermann Benedikt Schrage
author_sort	Michal Pazdernik
title	Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
title_short	Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
title_full	Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
title_fullStr	Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
title_full_unstemmed	Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
title_sort	regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: results from multicenter, international registry
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/4fe278ca854e4e1a91040e5e0e4fbfcb
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Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry

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