A Genetic Map of the Modern Urban Society of Amsterdam

Genetic differences between individuals underlie susceptibility to many diseases. Genome-wide association studies (GWAS) have discovered many susceptibility genes but were often limited to cohorts of predominantly European ancestry. Genetic diversity between individuals due to different ancestries a...

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Autores principales:	Bart Ferwerda, Abdel Abdellaoui, Max Nieuwdorp, Koos Zwinderman
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	HELIUS multiethnic cohort admixture genetics GWAS Genetics QH426-470
Acceso en línea:	https://doaj.org/article/4fe345b38e72449d9256481a788e6a16
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id	oai:doaj.org-article:4fe345b38e72449d9256481a788e6a16
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spelling	oai:doaj.org-article:4fe345b38e72449d9256481a788e6a162021-12-01T20:04:07ZA Genetic Map of the Modern Urban Society of Amsterdam1664-802110.3389/fgene.2021.727269https://doaj.org/article/4fe345b38e72449d9256481a788e6a162021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.727269/fullhttps://doaj.org/toc/1664-8021Genetic differences between individuals underlie susceptibility to many diseases. Genome-wide association studies (GWAS) have discovered many susceptibility genes but were often limited to cohorts of predominantly European ancestry. Genetic diversity between individuals due to different ancestries and evolutionary histories shows that this approach has limitations. In order to gain a better understanding of the associated genetic variation, we need a more global genomics approach including a greater diversity. Here, we introduce the Healthy Life in an Urban Setting (HELIUS) cohort. The HELIUS cohort consists of participants living in Amsterdam, with a level of diversity that reflects the Dutch colonial and recent migration past. The current study includes 10,283 participants with genetic data available from seven groups of inhabitants, namely, Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, Ghanaian, and Javanese Surinamese. First, we describe the genetic variation and admixture within the HELIUS cohort. Second, we show the challenges during imputation when having a genetically diverse cohort. Third, we conduct a body mass index (BMI) and height GWAS where we investigate the effects of a joint analysis of the entire cohort and a meta-analysis approach for the different subgroups. Finally, we construct polygenic scores for BMI and height and compare their predictive power across the different ethnic groups. Overall, we give a comprehensive overview of a genetically diverse cohort from Amsterdam. Our study emphasizes the importance of a less biased and more realistic representation of urban populations for mapping genetic associations with complex traits and disease risk for all.Bart FerwerdaAbdel AbdellaouiMax NieuwdorpMax NieuwdorpMax NieuwdorpKoos ZwindermanFrontiers Media S.A.articleHELIUSmultiethnic cohortadmixturegeneticsGWASGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HELIUS multiethnic cohort admixture genetics GWAS Genetics QH426-470
spellingShingle	HELIUS multiethnic cohort admixture genetics GWAS Genetics QH426-470 Bart Ferwerda Abdel Abdellaoui Max Nieuwdorp Max Nieuwdorp Max Nieuwdorp Koos Zwinderman A Genetic Map of the Modern Urban Society of Amsterdam
description	Genetic differences between individuals underlie susceptibility to many diseases. Genome-wide association studies (GWAS) have discovered many susceptibility genes but were often limited to cohorts of predominantly European ancestry. Genetic diversity between individuals due to different ancestries and evolutionary histories shows that this approach has limitations. In order to gain a better understanding of the associated genetic variation, we need a more global genomics approach including a greater diversity. Here, we introduce the Healthy Life in an Urban Setting (HELIUS) cohort. The HELIUS cohort consists of participants living in Amsterdam, with a level of diversity that reflects the Dutch colonial and recent migration past. The current study includes 10,283 participants with genetic data available from seven groups of inhabitants, namely, Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, Ghanaian, and Javanese Surinamese. First, we describe the genetic variation and admixture within the HELIUS cohort. Second, we show the challenges during imputation when having a genetically diverse cohort. Third, we conduct a body mass index (BMI) and height GWAS where we investigate the effects of a joint analysis of the entire cohort and a meta-analysis approach for the different subgroups. Finally, we construct polygenic scores for BMI and height and compare their predictive power across the different ethnic groups. Overall, we give a comprehensive overview of a genetically diverse cohort from Amsterdam. Our study emphasizes the importance of a less biased and more realistic representation of urban populations for mapping genetic associations with complex traits and disease risk for all.
format	article
author	Bart Ferwerda Abdel Abdellaoui Max Nieuwdorp Max Nieuwdorp Max Nieuwdorp Koos Zwinderman
author_facet	Bart Ferwerda Abdel Abdellaoui Max Nieuwdorp Max Nieuwdorp Max Nieuwdorp Koos Zwinderman
author_sort	Bart Ferwerda
title	A Genetic Map of the Modern Urban Society of Amsterdam
title_short	A Genetic Map of the Modern Urban Society of Amsterdam
title_full	A Genetic Map of the Modern Urban Society of Amsterdam
title_fullStr	A Genetic Map of the Modern Urban Society of Amsterdam
title_full_unstemmed	A Genetic Map of the Modern Urban Society of Amsterdam
title_sort	genetic map of the modern urban society of amsterdam
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4fe345b38e72449d9256481a788e6a16
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A Genetic Map of the Modern Urban Society of Amsterdam

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