Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier

Abstract Porphyrin derivatives accumulate selectively in cancer cells and are can be used as carriers of drugs. Until now, the substituents that bind to porphyrins (mainly at the meso-position) have been actively investigated, but the effect of the functional porphyrin positions (β-, meso-position)...

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Autores principales:	Koshi Nishida, Toshifumi Tojo, Takeshi Kondo, Makoto Yuasa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4fe4737659d14ca9bbbb1a2633d6ba65
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spelling	oai:doaj.org-article:4fe4737659d14ca9bbbb1a2633d6ba652021-12-02T13:57:05ZEvaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier10.1038/s41598-021-81725-32045-2322https://doaj.org/article/4fe4737659d14ca9bbbb1a2633d6ba652021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81725-3https://doaj.org/toc/2045-2322Abstract Porphyrin derivatives accumulate selectively in cancer cells and are can be used as carriers of drugs. Until now, the substituents that bind to porphyrins (mainly at the meso-position) have been actively investigated, but the effect of the functional porphyrin positions (β-, meso-position) on tumor accumulation has not been investigated. Therefore, we investigated the correlation between the functional position of substituents and the accumulation of porphyrins in cancer cells using cancer cells. We found that the meso-derivative showed higher accumulation in cancer cells than the β-derivative, and porphyrins with less bulky substituent actively accumulate in cancer cells. When evaluating the intracellular distribution of porphyrin, we found that porphyrin was internalized by endocytosis and direct membrane permeation. As factors involved in these two permeation mechanisms, we evaluated the affinity between porphyrin-protein (endocytosis) and the permeability to the phospholipid bilayer membrane (direct membrane permeation). We found that the binding position of porphyrin affects the factors involved in the transmembrane permeation mechanisms and impacts the accumulation in cancer cells.Koshi NishidaToshifumi TojoTakeshi KondoMakoto YuasaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koshi Nishida Toshifumi Tojo Takeshi Kondo Makoto Yuasa Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
description	Abstract Porphyrin derivatives accumulate selectively in cancer cells and are can be used as carriers of drugs. Until now, the substituents that bind to porphyrins (mainly at the meso-position) have been actively investigated, but the effect of the functional porphyrin positions (β-, meso-position) on tumor accumulation has not been investigated. Therefore, we investigated the correlation between the functional position of substituents and the accumulation of porphyrins in cancer cells using cancer cells. We found that the meso-derivative showed higher accumulation in cancer cells than the β-derivative, and porphyrins with less bulky substituent actively accumulate in cancer cells. When evaluating the intracellular distribution of porphyrin, we found that porphyrin was internalized by endocytosis and direct membrane permeation. As factors involved in these two permeation mechanisms, we evaluated the affinity between porphyrin-protein (endocytosis) and the permeability to the phospholipid bilayer membrane (direct membrane permeation). We found that the binding position of porphyrin affects the factors involved in the transmembrane permeation mechanisms and impacts the accumulation in cancer cells.
format	article
author	Koshi Nishida Toshifumi Tojo Takeshi Kondo Makoto Yuasa
author_facet	Koshi Nishida Toshifumi Tojo Takeshi Kondo Makoto Yuasa
author_sort	Koshi Nishida
title	Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
title_short	Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
title_full	Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
title_fullStr	Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
title_full_unstemmed	Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
title_sort	evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4fe4737659d14ca9bbbb1a2633d6ba65
work_keys_str_mv	AT koshinishida evaluationofthecorrelationbetweenporphyrinaccumulationincancercellsandfunctionalpositionsforapplicationasadrugcarrier AT toshifumitojo evaluationofthecorrelationbetweenporphyrinaccumulationincancercellsandfunctionalpositionsforapplicationasadrugcarrier AT takeshikondo evaluationofthecorrelationbetweenporphyrinaccumulationincancercellsandfunctionalpositionsforapplicationasadrugcarrier AT makotoyuasa evaluationofthecorrelationbetweenporphyrinaccumulationincancercellsandfunctionalpositionsforapplicationasadrugcarrier
_version_	1718392319787401216

Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier

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