Fusobacterium nucleatum and oral cancer: a critical review
Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal can...
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2021
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oai:doaj.org-article:4fe7821000194282b227188231027b4b2021-11-14T12:30:33ZFusobacterium nucleatum and oral cancer: a critical review10.1186/s12885-021-08903-41471-2407https://doaj.org/article/4fe7821000194282b227188231027b4b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08903-4https://doaj.org/toc/1471-2407Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.Emily McIlvannaGerard J. LindenStephanie G. CraigFionnuala T. LundyJacqueline A. JamesBMCarticleFusobacteriaF. nucleatumCarcinogenesisOral cancerOSCCNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021) |
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Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Emily McIlvanna Gerard J. Linden Stephanie G. Craig Fionnuala T. Lundy Jacqueline A. James Fusobacterium nucleatum and oral cancer: a critical review |
description |
Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it. |
format |
article |
author |
Emily McIlvanna Gerard J. Linden Stephanie G. Craig Fionnuala T. Lundy Jacqueline A. James |
author_facet |
Emily McIlvanna Gerard J. Linden Stephanie G. Craig Fionnuala T. Lundy Jacqueline A. James |
author_sort |
Emily McIlvanna |
title |
Fusobacterium nucleatum and oral cancer: a critical review |
title_short |
Fusobacterium nucleatum and oral cancer: a critical review |
title_full |
Fusobacterium nucleatum and oral cancer: a critical review |
title_fullStr |
Fusobacterium nucleatum and oral cancer: a critical review |
title_full_unstemmed |
Fusobacterium nucleatum and oral cancer: a critical review |
title_sort |
fusobacterium nucleatum and oral cancer: a critical review |
publisher |
BMC |
publishDate |
2021 |
url |
https://doaj.org/article/4fe7821000194282b227188231027b4b |
work_keys_str_mv |
AT emilymcilvanna fusobacteriumnucleatumandoralcanceracriticalreview AT gerardjlinden fusobacteriumnucleatumandoralcanceracriticalreview AT stephaniegcraig fusobacteriumnucleatumandoralcanceracriticalreview AT fionnualatlundy fusobacteriumnucleatumandoralcanceracriticalreview AT jacquelineajames fusobacteriumnucleatumandoralcanceracriticalreview |
_version_ |
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