Fusobacterium nucleatum and oral cancer: a critical review

Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal can...

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Autores principales: Emily McIlvanna, Gerard J. Linden, Stephanie G. Craig, Fionnuala T. Lundy, Jacqueline A. James
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Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/4fe7821000194282b227188231027b4b
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spelling oai:doaj.org-article:4fe7821000194282b227188231027b4b2021-11-14T12:30:33ZFusobacterium nucleatum and oral cancer: a critical review10.1186/s12885-021-08903-41471-2407https://doaj.org/article/4fe7821000194282b227188231027b4b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08903-4https://doaj.org/toc/1471-2407Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.Emily McIlvannaGerard J. LindenStephanie G. CraigFionnuala T. LundyJacqueline A. JamesBMCarticleFusobacteriaF. nucleatumCarcinogenesisOral cancerOSCCNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Fusobacteria
F. nucleatum
Carcinogenesis
Oral cancer
OSCC
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Fusobacteria
F. nucleatum
Carcinogenesis
Oral cancer
OSCC
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Emily McIlvanna
Gerard J. Linden
Stephanie G. Craig
Fionnuala T. Lundy
Jacqueline A. James
Fusobacterium nucleatum and oral cancer: a critical review
description Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.
format article
author Emily McIlvanna
Gerard J. Linden
Stephanie G. Craig
Fionnuala T. Lundy
Jacqueline A. James
author_facet Emily McIlvanna
Gerard J. Linden
Stephanie G. Craig
Fionnuala T. Lundy
Jacqueline A. James
author_sort Emily McIlvanna
title Fusobacterium nucleatum and oral cancer: a critical review
title_short Fusobacterium nucleatum and oral cancer: a critical review
title_full Fusobacterium nucleatum and oral cancer: a critical review
title_fullStr Fusobacterium nucleatum and oral cancer: a critical review
title_full_unstemmed Fusobacterium nucleatum and oral cancer: a critical review
title_sort fusobacterium nucleatum and oral cancer: a critical review
publisher BMC
publishDate 2021
url https://doaj.org/article/4fe7821000194282b227188231027b4b
work_keys_str_mv AT emilymcilvanna fusobacteriumnucleatumandoralcanceracriticalreview
AT gerardjlinden fusobacteriumnucleatumandoralcanceracriticalreview
AT stephaniegcraig fusobacteriumnucleatumandoralcanceracriticalreview
AT fionnualatlundy fusobacteriumnucleatumandoralcanceracriticalreview
AT jacquelineajames fusobacteriumnucleatumandoralcanceracriticalreview
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