Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the...

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Autores principales:	Abhimanyu Thakur, Diana Carolina Parra, Pedram Motallebnejad, Marcelo Brocchi, Huanhuan Joyce Chen
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4fe7bf9245e34e69a2c434136dc1f6b0
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spelling	oai:doaj.org-article:4fe7bf9245e34e69a2c434136dc1f6b02021-11-28T04:35:19ZExosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics2452-199X10.1016/j.bioactmat.2021.08.029https://doaj.org/article/4fe7bf9245e34e69a2c434136dc1f6b02022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004059https://doaj.org/toc/2452-199XCancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the therapeutic potential of their various components including proteins, lipids, nucleic acids, miRNAs, and lncRNAs. Exosomes constitute a set of tiny extracellular vesicles with an approximate diameter of 30–100 nm. They are released from different cells and are present in biofluids including blood, cerebrospinal fluid (CSF), and urine. They perform crucial multifaceted functions in the malignant progression of cancer via autocrine, paracrine, and endocrine communications. The ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer therapeutics. In this review, we discuss the major components of exosomes and their role in cancer progression. We also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics.Abhimanyu ThakurDiana Carolina ParraPedram MotallebnejadMarcelo BrocchiHuanhuan Joyce ChenKeAi Communications Co., Ltd.articleCancerExosomeTherapeuticsExtracellular vesiclesExosomal vaccineExosomal delivery systemMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 281-294 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan Joyce Chen Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
description	Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the therapeutic potential of their various components including proteins, lipids, nucleic acids, miRNAs, and lncRNAs. Exosomes constitute a set of tiny extracellular vesicles with an approximate diameter of 30–100 nm. They are released from different cells and are present in biofluids including blood, cerebrospinal fluid (CSF), and urine. They perform crucial multifaceted functions in the malignant progression of cancer via autocrine, paracrine, and endocrine communications. The ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer therapeutics. In this review, we discuss the major components of exosomes and their role in cancer progression. We also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics.
format	article
author	Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan Joyce Chen
author_facet	Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan Joyce Chen
author_sort	Abhimanyu Thakur
title	Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
title_short	Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
title_full	Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
title_fullStr	Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
title_full_unstemmed	Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
title_sort	exosomes: small vesicles with big roles in cancer, vaccine development, and therapeutics
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/4fe7bf9245e34e69a2c434136dc1f6b0
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Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

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