Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models

Abstract ApoEε4 is a major genetic risk factor for Alzheimer’s disease (AD), a disease hallmarked by extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). The presence of the ApoEε4 allele is associated with increased Aβ deposition and a role for ApoEε4 in the pot...

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Autores principales: Angela Marie Jablonski, Lee Warren, Marija Usenovic, Heather Zhou, Jonathan Sugam, Sophie Parmentier-Batteur, Bhavya Voleti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4fe83d6941c44b5bbe01ae4d30b636f0
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