Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers
Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A.
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2016
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oai:doaj.org-article:4fec995c232548e9812db54cfb2540792021-12-02T17:33:21ZLineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers10.1038/ncomms134182041-1723https://doaj.org/article/4fec995c232548e9812db54cfb2540792016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13418https://doaj.org/toc/2041-1723Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A.Eva Pérez-GuijarroPanagiotis KarrasMetehan CifdalozRaúl Martínez-HerranzEstela CañónOsvaldo GrañaCelia Horcajada-RealesDirena Alonso-CurbeloTonantzin G. CalvoGonzalo Gómez-LópezNicolas BelloraErica Riveiro-FalkenbachPablo L. Ortiz-RomeroJosé L. Rodríguez-PeraltoLorena MaestreGiovanna RoncadorJuan C. de Agustín AsensioColin R. GodingEduardo EyrasDiego MegíasRaúl MéndezMaría S. SoengasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Eva Pérez-Guijarro Panagiotis Karras Metehan Cifdaloz Raúl Martínez-Herranz Estela Cañón Osvaldo Graña Celia Horcajada-Reales Direna Alonso-Curbelo Tonantzin G. Calvo Gonzalo Gómez-López Nicolas Bellora Erica Riveiro-Falkenbach Pablo L. Ortiz-Romero José L. Rodríguez-Peralto Lorena Maestre Giovanna Roncador Juan C. de Agustín Asensio Colin R. Goding Eduardo Eyras Diego Megías Raúl Méndez María S. Soengas Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers |
| description |
Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A. |
| format |
article |
| author |
Eva Pérez-Guijarro Panagiotis Karras Metehan Cifdaloz Raúl Martínez-Herranz Estela Cañón Osvaldo Graña Celia Horcajada-Reales Direna Alonso-Curbelo Tonantzin G. Calvo Gonzalo Gómez-López Nicolas Bellora Erica Riveiro-Falkenbach Pablo L. Ortiz-Romero José L. Rodríguez-Peralto Lorena Maestre Giovanna Roncador Juan C. de Agustín Asensio Colin R. Goding Eduardo Eyras Diego Megías Raúl Méndez María S. Soengas |
| author_facet |
Eva Pérez-Guijarro Panagiotis Karras Metehan Cifdaloz Raúl Martínez-Herranz Estela Cañón Osvaldo Graña Celia Horcajada-Reales Direna Alonso-Curbelo Tonantzin G. Calvo Gonzalo Gómez-López Nicolas Bellora Erica Riveiro-Falkenbach Pablo L. Ortiz-Romero José L. Rodríguez-Peralto Lorena Maestre Giovanna Roncador Juan C. de Agustín Asensio Colin R. Goding Eduardo Eyras Diego Megías Raúl Méndez María S. Soengas |
| author_sort |
Eva Pérez-Guijarro |
| title |
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers |
| title_short |
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers |
| title_full |
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers |
| title_fullStr |
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers |
| title_full_unstemmed |
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers |
| title_sort |
lineage-specific roles of the cytoplasmic polyadenylation factor cpeb4 in the regulation of melanoma drivers |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/4fec995c232548e9812db54cfb254079 |
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