Staging lung cancer: role of endobronchial ultrasound

Terunaga Inage, Takahiro Nakajima, Ichiro Yoshino Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Abstract: Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge t...

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Autores principales:	Inage T, Nakajima T, Yoshino I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4fef85a6cb9747dd8501d5eb47966fab
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spelling	oai:doaj.org-article:4fef85a6cb9747dd8501d5eb47966fab2021-12-02T08:43:25ZStaging lung cancer: role of endobronchial ultrasound1179-2728https://doaj.org/article/4fef85a6cb9747dd8501d5eb47966fab2014-11-01T00:00:00Zhttp://www.dovepress.com/staging-lung-cancer-role-of-endobronchial-ultrasound-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728 Terunaga Inage, Takahiro Nakajima, Ichiro Yoshino Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Abstract: Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge the primary operability of patients harboring no distant metastasis. For many years, mediastinoscopy has been considered a “gold standard” modality for nodal staging. Mediastinoscopy is known to be a highly sensitive procedure for mediastinal staging and has been performed worldwide, but is invasive. Because of this, clinicians have sought a less invasive modality for nodal staging. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive modality for diagnosis and staging of lung cancer. EBUS-TBNA is a needle biopsy procedure that has accessibility compatible with the reach of the convex-probe EBUS scope, so N1 nodes are also assessable. The diagnostic yield is similar to that of mediastinoscopy, and the core obtained by the dedicated needle biopsy can be used for histological assessment to determine the subtypes of lung cancer. The samples can also be used to test for various biomarkers using immunohistochemistry, polymerase chain reaction for DNA/complementary DNA, and in situ hybridization, and the technique is useful for selecting candidates for specific molecular-targeted therapeutic agents. According to the newly published American College of Chest Physicians guideline, EBUS-TBNA is now considered "the best first test" for nodal staging in patients with radiologically suspicious nodes. Appropriate training and thorough clinical experience is required to be able to perform correct nodal staging using this procedure. Keywords: lung cancer, staging, endobronchial ultrasound, transbronchial biopsyInage TNakajima TYoshino IDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol 2014, Iss default, Pp 67-72 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Inage T Nakajima T Yoshino I Staging lung cancer: role of endobronchial ultrasound
description	Terunaga Inage, Takahiro Nakajima, Ichiro Yoshino Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Abstract: Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge the primary operability of patients harboring no distant metastasis. For many years, mediastinoscopy has been considered a “gold standard” modality for nodal staging. Mediastinoscopy is known to be a highly sensitive procedure for mediastinal staging and has been performed worldwide, but is invasive. Because of this, clinicians have sought a less invasive modality for nodal staging. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive modality for diagnosis and staging of lung cancer. EBUS-TBNA is a needle biopsy procedure that has accessibility compatible with the reach of the convex-probe EBUS scope, so N1 nodes are also assessable. The diagnostic yield is similar to that of mediastinoscopy, and the core obtained by the dedicated needle biopsy can be used for histological assessment to determine the subtypes of lung cancer. The samples can also be used to test for various biomarkers using immunohistochemistry, polymerase chain reaction for DNA/complementary DNA, and in situ hybridization, and the technique is useful for selecting candidates for specific molecular-targeted therapeutic agents. According to the newly published American College of Chest Physicians guideline, EBUS-TBNA is now considered "the best first test" for nodal staging in patients with radiologically suspicious nodes. Appropriate training and thorough clinical experience is required to be able to perform correct nodal staging using this procedure. Keywords: lung cancer, staging, endobronchial ultrasound, transbronchial biopsy
format	article
author	Inage T Nakajima T Yoshino I
author_facet	Inage T Nakajima T Yoshino I
author_sort	Inage T
title	Staging lung cancer: role of endobronchial ultrasound
title_short	Staging lung cancer: role of endobronchial ultrasound
title_full	Staging lung cancer: role of endobronchial ultrasound
title_fullStr	Staging lung cancer: role of endobronchial ultrasound
title_full_unstemmed	Staging lung cancer: role of endobronchial ultrasound
title_sort	staging lung cancer: role of endobronchial ultrasound
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/4fef85a6cb9747dd8501d5eb47966fab
work_keys_str_mv	AT inaget staginglungcancerroleofendobronchialultrasound AT nakajimat staginglungcancerroleofendobronchialultrasound AT yoshinoi staginglungcancerroleofendobronchialultrasound
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Staging lung cancer: role of endobronchial ultrasound

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