The evolving definition of salivary gland stem cells

Abstract Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality of life of the patients. Approaches aimed at regenerating damaged salivary glands have been proposed as...

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Autores principales:	Cecilia Rocchi, Lara Barazzuol, Rob P. Coppes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/4ff52a72b99d41719bd822070fa3080b
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spelling	oai:doaj.org-article:4ff52a72b99d41719bd822070fa3080b2021-12-02T14:40:00ZThe evolving definition of salivary gland stem cells10.1038/s41536-020-00115-x2057-3995https://doaj.org/article/4ff52a72b99d41719bd822070fa3080b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41536-020-00115-xhttps://doaj.org/toc/2057-3995Abstract Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality of life of the patients. Approaches aimed at regenerating damaged salivary glands have been proposed as means to provide long-term restoration of tissue function in the affected patients. In studies to elucidate salivary gland regenerative mechanisms, more and more evidence suggests that salivary gland stem/progenitor cell behavior, like many other adult tissues, does not follow that of the hard-wired professional stem cells of the hematopoietic system. In this review, we provide evidence showing that several cell types within the salivary gland epithelium can serve as stem/progenitor-like cells. While these cell populations seem to function mostly as lineage-restricted progenitors during homeostasis, we indicate that upon damage specific plasticity mechanisms might be activated to take part in regeneration of the tissue. In light of these insights, we provide an overview of how recent developments in the adult stem cell research field are changing our thinking of the definition of salivary gland stem cells and their potential plasticity upon damage. These new perspectives may have important implications on the development of new therapeutic approaches to rescue radiation-induced hyposalivation.Cecilia RocchiLara BarazzuolRob P. CoppesNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Cecilia Rocchi Lara Barazzuol Rob P. Coppes The evolving definition of salivary gland stem cells
description	Abstract Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality of life of the patients. Approaches aimed at regenerating damaged salivary glands have been proposed as means to provide long-term restoration of tissue function in the affected patients. In studies to elucidate salivary gland regenerative mechanisms, more and more evidence suggests that salivary gland stem/progenitor cell behavior, like many other adult tissues, does not follow that of the hard-wired professional stem cells of the hematopoietic system. In this review, we provide evidence showing that several cell types within the salivary gland epithelium can serve as stem/progenitor-like cells. While these cell populations seem to function mostly as lineage-restricted progenitors during homeostasis, we indicate that upon damage specific plasticity mechanisms might be activated to take part in regeneration of the tissue. In light of these insights, we provide an overview of how recent developments in the adult stem cell research field are changing our thinking of the definition of salivary gland stem cells and their potential plasticity upon damage. These new perspectives may have important implications on the development of new therapeutic approaches to rescue radiation-induced hyposalivation.
format	article
author	Cecilia Rocchi Lara Barazzuol Rob P. Coppes
author_facet	Cecilia Rocchi Lara Barazzuol Rob P. Coppes
author_sort	Cecilia Rocchi
title	The evolving definition of salivary gland stem cells
title_short	The evolving definition of salivary gland stem cells
title_full	The evolving definition of salivary gland stem cells
title_fullStr	The evolving definition of salivary gland stem cells
title_full_unstemmed	The evolving definition of salivary gland stem cells
title_sort	evolving definition of salivary gland stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ff52a72b99d41719bd822070fa3080b
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The evolving definition of salivary gland stem cells

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