Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review

Andrea Russo, Ivano Riva, Teodoro Pizzolante, Federico Noto, Luciano QuarantaCattedra di Malattie dell&rsquo;Apparato Visivo, Universit&agrave; degli studi di Brescia, USVD &ldquo;Centro per lo studio del Glaucoma&rdquo; Spedali Civili di BresciaAbstract: Latanoprost...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrea Russo, Ivano Riva, Teodoro Pizzolante, Federico Noto, Luciano Quaranta
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4ff5fad9208f4d4dac68f95d5b98d64c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ff5fad9208f4d4dac68f95d5b98d64c
record_format	dspace
spelling	oai:doaj.org-article:4ff5fad9208f4d4dac68f95d5b98d64c2021-12-02T05:07:19ZLatanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review1177-54671177-5483https://doaj.org/article/4ff5fad9208f4d4dac68f95d5b98d64c2009-01-01T00:00:00Zhttp://www.dovepress.com/latanoprost-ophthalmic-solution-in-the-treatment-of-open-angle-glaucom-a2801https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Andrea Russo, Ivano Riva, Teodoro Pizzolante, Federico Noto, Luciano QuarantaCattedra di Malattie dell&rsquo;Apparato Visivo, Universit&agrave; degli studi di Brescia, USVD &ldquo;Centro per lo studio del Glaucoma&rdquo; Spedali Civili di BresciaAbstract: Latanoprost is a prostaglandin F2-alpha isopropyl ester prodrug which is rapidly hydrolyzed by esterases in the cornea to the biologically active latanoprost acid. When latanoprost is topically administered into the eye, the cornea seems to act like as a slow-release depot to the anterior segment. One hour after administration maximum concentration is found in the iris, followed by the anterior chamber and the ciliary body. Despite extensive research, controversy remains about the real mechanism of action of this drug. Immunohistochemical data have shown that the intraocular pressure (IOP) reduction with topical prostaglandin F2-alpha is associated with a reduction of collagens within the uveoscleral outflow pathway. Evidence from several experimental and clinical studies suggests that latanoprost is a valuable addition first-line treatment alternatives for glaucoma, ocular hypertension and even angle-closure glaucoma. Strong points are its efficacy, which is demonstrated to be higher than that of brimonidine, dorzolamide and timolol with fewer systemic adverse effects; a convenient administration schedule; and the IOP-controlling pattern, which is relatively flat compared with timolol and dorzolamide, and enables better control in glaucoma progression, since large fluctuations may be associated with the risk of developing glaucoma in untreated ocular hypertensive subjects.Keywords: latanoprost, intraocular pressure, glaucoma, ocular hypertension Andrea RussoIvano RivaTeodoro PizzolanteFederico NotoLuciano QuarantaDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 4, Pp 897-905 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Andrea Russo Ivano Riva Teodoro Pizzolante Federico Noto Luciano Quaranta Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
description	Andrea Russo, Ivano Riva, Teodoro Pizzolante, Federico Noto, Luciano QuarantaCattedra di Malattie dell&rsquo;Apparato Visivo, Universit&agrave; degli studi di Brescia, USVD &ldquo;Centro per lo studio del Glaucoma&rdquo; Spedali Civili di BresciaAbstract: Latanoprost is a prostaglandin F2-alpha isopropyl ester prodrug which is rapidly hydrolyzed by esterases in the cornea to the biologically active latanoprost acid. When latanoprost is topically administered into the eye, the cornea seems to act like as a slow-release depot to the anterior segment. One hour after administration maximum concentration is found in the iris, followed by the anterior chamber and the ciliary body. Despite extensive research, controversy remains about the real mechanism of action of this drug. Immunohistochemical data have shown that the intraocular pressure (IOP) reduction with topical prostaglandin F2-alpha is associated with a reduction of collagens within the uveoscleral outflow pathway. Evidence from several experimental and clinical studies suggests that latanoprost is a valuable addition first-line treatment alternatives for glaucoma, ocular hypertension and even angle-closure glaucoma. Strong points are its efficacy, which is demonstrated to be higher than that of brimonidine, dorzolamide and timolol with fewer systemic adverse effects; a convenient administration schedule; and the IOP-controlling pattern, which is relatively flat compared with timolol and dorzolamide, and enables better control in glaucoma progression, since large fluctuations may be associated with the risk of developing glaucoma in untreated ocular hypertensive subjects.Keywords: latanoprost, intraocular pressure, glaucoma, ocular hypertension
format	article
author	Andrea Russo Ivano Riva Teodoro Pizzolante Federico Noto Luciano Quaranta
author_facet	Andrea Russo Ivano Riva Teodoro Pizzolante Federico Noto Luciano Quaranta
author_sort	Andrea Russo
title	Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
title_short	Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
title_full	Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
title_fullStr	Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
title_full_unstemmed	Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
title_sort	latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/4ff5fad9208f4d4dac68f95d5b98d64c
work_keys_str_mv	AT andrearusso latanoprostophthalmicsolutioninthetreatmentofopenangleglaucomaorraisedintraocularpressureareview AT ivanoriva latanoprostophthalmicsolutioninthetreatmentofopenangleglaucomaorraisedintraocularpressureareview AT teodoropizzolante latanoprostophthalmicsolutioninthetreatmentofopenangleglaucomaorraisedintraocularpressureareview AT federiconoto latanoprostophthalmicsolutioninthetreatmentofopenangleglaucomaorraisedintraocularpressureareview AT lucianoquaranta latanoprostophthalmicsolutioninthetreatmentofopenangleglaucomaorraisedintraocularpressureareview
_version_	1718400588900728832

Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review

Ejemplares similares