Single-molecule theory of enzymatic inhibition

Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.

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Detalles Bibliográficos
Autores principales:	Tal Robin, Shlomi Reuveni, Michael Urbakh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ff682a5b6ec47f9b1d180b0cef1fdf2
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spelling	oai:doaj.org-article:4ff682a5b6ec47f9b1d180b0cef1fdf22021-12-02T16:50:08ZSingle-molecule theory of enzymatic inhibition10.1038/s41467-018-02995-62041-1723https://doaj.org/article/4ff682a5b6ec47f9b1d180b0cef1fdf22018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02995-6https://doaj.org/toc/2041-1723Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.Tal RobinShlomi ReuveniMichael UrbakhNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tal Robin Shlomi Reuveni Michael Urbakh Single-molecule theory of enzymatic inhibition
description	Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.
format	article
author	Tal Robin Shlomi Reuveni Michael Urbakh
author_facet	Tal Robin Shlomi Reuveni Michael Urbakh
author_sort	Tal Robin
title	Single-molecule theory of enzymatic inhibition
title_short	Single-molecule theory of enzymatic inhibition
title_full	Single-molecule theory of enzymatic inhibition
title_fullStr	Single-molecule theory of enzymatic inhibition
title_full_unstemmed	Single-molecule theory of enzymatic inhibition
title_sort	single-molecule theory of enzymatic inhibition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4ff682a5b6ec47f9b1d180b0cef1fdf2
work_keys_str_mv	AT talrobin singlemoleculetheoryofenzymaticinhibition AT shlomireuveni singlemoleculetheoryofenzymaticinhibition AT michaelurbakh singlemoleculetheoryofenzymaticinhibition
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Single-molecule theory of enzymatic inhibition

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