A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models

Elizabeth Pearce,1 Sobha Sivaprasad1,2 1Department of Ocular Biology, Institute of Ophthalmology, University College London, London, UK; 2Medical Retina Department, NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UKCorrespondence: Sobha SivaprasadNIHR Moorfields Biomedic...

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Autores principales:	Pearce E, Sivaprasad S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	telescreening non-proliferative diabetic retinopathy risk-stratification systematic opportunistic Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4ff958152c15437faafaecdd9f7fbd8c
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spelling	oai:doaj.org-article:4ff958152c15437faafaecdd9f7fbd8c2021-12-02T12:10:30ZA Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models1177-5483https://doaj.org/article/4ff958152c15437faafaecdd9f7fbd8c2020-10-01T00:00:00Zhttps://www.dovepress.com/a-review-of-advancements-and-evidence-gaps-in-diabetic-retinopathy-scr-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Elizabeth Pearce,1 Sobha Sivaprasad1,2 1Department of Ocular Biology, Institute of Ophthalmology, University College London, London, UK; 2Medical Retina Department, NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UKCorrespondence: Sobha SivaprasadNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London EC1V 2PD, UKTel +44 20 7253 3411Email senswathi@aol.comAbstract: Diabetic retinopathy (DR) is a microvascular complication of diabetes with a prevalence of &sim; 35%, and is one of the leading causes of visual impairment in people of working age in most developed countries. The earliest stage of DR, non-proliferative DR (NPDR), may progress to sight-threatening DR (STDR). Thus, early detection of DR and active regular screening of patients with diabetes are necessary for earlier intervention to prevent sight loss. While some countries offer systematic DR screening, most nations are reliant on opportunistic screening or do not offer any screening owing to limited healthcare resources and infrastructure. Currently, retinal imaging approaches for DR screening include those with and without mydriasis, imaging in single or multiple fields, and the use of conventional or ultra-wide-field imaging. Advances in telescreening and automated detection facilitate screening in previously hard-to-reach communities. Despite the heterogeneity in approaches to fit local needs, an evidence base must be created for each model to inform practice. In this review, we appraise different aspects of DR screening, including technological advances, identify evidence gaps, and propose several studies to improve DR screening globally, with a view to identifying patients with moderate-to-severe NPDR who would benefit if a convenient treatment option to delay progression to STDR became available.Keywords: telescreening, non-proliferative diabetic retinopathy, risk-stratification, systematic, opportunisticPearce ESivaprasad SDove Medical Pressarticletelescreeningnon-proliferative diabetic retinopathyrisk-stratificationsystematicopportunisticOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3285-3296 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	telescreening non-proliferative diabetic retinopathy risk-stratification systematic opportunistic Ophthalmology RE1-994
spellingShingle	telescreening non-proliferative diabetic retinopathy risk-stratification systematic opportunistic Ophthalmology RE1-994 Pearce E Sivaprasad S A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
description	Elizabeth Pearce,1 Sobha Sivaprasad1,2 1Department of Ocular Biology, Institute of Ophthalmology, University College London, London, UK; 2Medical Retina Department, NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UKCorrespondence: Sobha SivaprasadNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London EC1V 2PD, UKTel +44 20 7253 3411Email senswathi@aol.comAbstract: Diabetic retinopathy (DR) is a microvascular complication of diabetes with a prevalence of &sim; 35%, and is one of the leading causes of visual impairment in people of working age in most developed countries. The earliest stage of DR, non-proliferative DR (NPDR), may progress to sight-threatening DR (STDR). Thus, early detection of DR and active regular screening of patients with diabetes are necessary for earlier intervention to prevent sight loss. While some countries offer systematic DR screening, most nations are reliant on opportunistic screening or do not offer any screening owing to limited healthcare resources and infrastructure. Currently, retinal imaging approaches for DR screening include those with and without mydriasis, imaging in single or multiple fields, and the use of conventional or ultra-wide-field imaging. Advances in telescreening and automated detection facilitate screening in previously hard-to-reach communities. Despite the heterogeneity in approaches to fit local needs, an evidence base must be created for each model to inform practice. In this review, we appraise different aspects of DR screening, including technological advances, identify evidence gaps, and propose several studies to improve DR screening globally, with a view to identifying patients with moderate-to-severe NPDR who would benefit if a convenient treatment option to delay progression to STDR became available.Keywords: telescreening, non-proliferative diabetic retinopathy, risk-stratification, systematic, opportunistic
format	article
author	Pearce E Sivaprasad S
author_facet	Pearce E Sivaprasad S
author_sort	Pearce E
title	A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
title_short	A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
title_full	A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
title_fullStr	A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
title_full_unstemmed	A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
title_sort	review of advancements and evidence gaps in diabetic retinopathy screening models
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/4ff958152c15437faafaecdd9f7fbd8c
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A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models

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