Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status

Abstract Body mass index (BMI) is well known to be associated with poor prognosis in several cancers. The relationship between BMI and the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC) is incompletely understood. This study investigated the relationships of BMI with clini...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kyohei Yugawa, Shinji Itoh, Norifumi Iseda, Takeshi Kurihara, Yoshiyuki Kitamura, Takeo Toshima, Noboru Harada, Kenichi Kohashi, Shingo Baba, Kousei Ishigami, Yoshinao Oda, Tomoharu Yoshizumi, Masaki Mori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4fff4491cf0a4f819f23332d08917e79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4fff4491cf0a4f819f23332d08917e79
record_format	dspace
spelling	oai:doaj.org-article:4fff4491cf0a4f819f23332d08917e792021-12-02T15:52:19ZObesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status10.1038/s41598-021-85186-62045-2322https://doaj.org/article/4fff4491cf0a4f819f23332d08917e792021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85186-6https://doaj.org/toc/2045-2322Abstract Body mass index (BMI) is well known to be associated with poor prognosis in several cancers. The relationship between BMI and the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC) is incompletely understood. This study investigated the relationships of BMI with clinicopathological characteristics and patient outcomes, focusing on metabolic activity and immune status. The relationship between BMI and the maximum standardized uptake value (SUVmax) on fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) was analyzed. In addition, immunohistochemistry was performed for programmed cell death-ligand 1 (PD-L1), cluster of differentiation 8 (CD8), and forkhead box protein P3 (Foxp3). Seventy-four patients with ICC were classified into normal weight (BMI < 25.0 kg/m2, n = 48) and obesity groups (BMI ≥ 25.0 kg/m2, n = 26), respectively. Serum carbohydrate antigen 19–9 levels were higher in the obesity group than in the normal weight group. Tumor size and the intrahepatic metastasis rate were significantly larger in the obesity group. Patients in the obesity group had significantly worse prognoses than those in the normal weight group. Moreover, BMI displayed a positive correlation with SUVmax on 18F-FDG PET/CT (n = 46, r = 0.5152). Patients with high 18F-FDG uptake had a significantly higher rate of PD-L1 expression, lower CD8 + tumor-infiltrating lymphocyte (TIL) counts, and higher Foxp3 + TIL counts. The elevated BMI might predict the outcomes of patients with ICC. Obesity might be associated with ICC progression, possibly through alterations in metabolic activity and the immune status.Kyohei YugawaShinji ItohNorifumi IsedaTakeshi KuriharaYoshiyuki KitamuraTakeo ToshimaNoboru HaradaKenichi KohashiShingo BabaKousei IshigamiYoshinao OdaTomoharu YoshizumiMasaki MoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyohei Yugawa Shinji Itoh Norifumi Iseda Takeshi Kurihara Yoshiyuki Kitamura Takeo Toshima Noboru Harada Kenichi Kohashi Shingo Baba Kousei Ishigami Yoshinao Oda Tomoharu Yoshizumi Masaki Mori Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
description	Abstract Body mass index (BMI) is well known to be associated with poor prognosis in several cancers. The relationship between BMI and the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC) is incompletely understood. This study investigated the relationships of BMI with clinicopathological characteristics and patient outcomes, focusing on metabolic activity and immune status. The relationship between BMI and the maximum standardized uptake value (SUVmax) on fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) was analyzed. In addition, immunohistochemistry was performed for programmed cell death-ligand 1 (PD-L1), cluster of differentiation 8 (CD8), and forkhead box protein P3 (Foxp3). Seventy-four patients with ICC were classified into normal weight (BMI < 25.0 kg/m2, n = 48) and obesity groups (BMI ≥ 25.0 kg/m2, n = 26), respectively. Serum carbohydrate antigen 19–9 levels were higher in the obesity group than in the normal weight group. Tumor size and the intrahepatic metastasis rate were significantly larger in the obesity group. Patients in the obesity group had significantly worse prognoses than those in the normal weight group. Moreover, BMI displayed a positive correlation with SUVmax on 18F-FDG PET/CT (n = 46, r = 0.5152). Patients with high 18F-FDG uptake had a significantly higher rate of PD-L1 expression, lower CD8 + tumor-infiltrating lymphocyte (TIL) counts, and higher Foxp3 + TIL counts. The elevated BMI might predict the outcomes of patients with ICC. Obesity might be associated with ICC progression, possibly through alterations in metabolic activity and the immune status.
format	article
author	Kyohei Yugawa Shinji Itoh Norifumi Iseda Takeshi Kurihara Yoshiyuki Kitamura Takeo Toshima Noboru Harada Kenichi Kohashi Shingo Baba Kousei Ishigami Yoshinao Oda Tomoharu Yoshizumi Masaki Mori
author_facet	Kyohei Yugawa Shinji Itoh Norifumi Iseda Takeshi Kurihara Yoshiyuki Kitamura Takeo Toshima Noboru Harada Kenichi Kohashi Shingo Baba Kousei Ishigami Yoshinao Oda Tomoharu Yoshizumi Masaki Mori
author_sort	Kyohei Yugawa
title	Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
title_short	Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
title_full	Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
title_fullStr	Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
title_full_unstemmed	Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
title_sort	obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4fff4491cf0a4f819f23332d08917e79
work_keys_str_mv	AT kyoheiyugawa obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT shinjiitoh obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT norifumiiseda obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT takeshikurihara obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT yoshiyukikitamura obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT takeotoshima obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT noboruharada obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT kenichikohashi obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT shingobaba obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT kouseiishigami obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT yoshinaooda obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT tomoharuyoshizumi obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus AT masakimori obesityisariskfactorforintrahepaticcholangiocarcinomaprogressionassociatedwithalterationsofmetabolicactivityandimmunestatus
_version_	1718385569896071168

Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status

Ejemplares similares