Calcium sensing by the STIM1 ER-luminal domain

Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, V. Rajanikanth, Andrey A. Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth A. Komives, Patrick G. Hogan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/500001afbcee44e78123ce02e0c9e9ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:500001afbcee44e78123ce02e0c9e9ab
record_format	dspace
spelling	oai:doaj.org-article:500001afbcee44e78123ce02e0c9e9ab2021-12-02T15:33:43ZCalcium sensing by the STIM1 ER-luminal domain10.1038/s41467-018-06816-82041-1723https://doaj.org/article/500001afbcee44e78123ce02e0c9e9ab2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06816-8https://doaj.org/toc/2041-1723Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.Aparna GudlurAna Eliza ZeraikNupura HirveV. RajanikanthAndrey A. BobkovGuolin MaSisi ZhengYoujun WangYubin ZhouElizabeth A. KomivesPatrick G. HoganNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aparna Gudlur Ana Eliza Zeraik Nupura Hirve V. Rajanikanth Andrey A. Bobkov Guolin Ma Sisi Zheng Youjun Wang Yubin Zhou Elizabeth A. Komives Patrick G. Hogan Calcium sensing by the STIM1 ER-luminal domain
description	Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.
format	article
author	Aparna Gudlur Ana Eliza Zeraik Nupura Hirve V. Rajanikanth Andrey A. Bobkov Guolin Ma Sisi Zheng Youjun Wang Yubin Zhou Elizabeth A. Komives Patrick G. Hogan
author_facet	Aparna Gudlur Ana Eliza Zeraik Nupura Hirve V. Rajanikanth Andrey A. Bobkov Guolin Ma Sisi Zheng Youjun Wang Yubin Zhou Elizabeth A. Komives Patrick G. Hogan
author_sort	Aparna Gudlur
title	Calcium sensing by the STIM1 ER-luminal domain
title_short	Calcium sensing by the STIM1 ER-luminal domain
title_full	Calcium sensing by the STIM1 ER-luminal domain
title_fullStr	Calcium sensing by the STIM1 ER-luminal domain
title_full_unstemmed	Calcium sensing by the STIM1 ER-luminal domain
title_sort	calcium sensing by the stim1 er-luminal domain
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/500001afbcee44e78123ce02e0c9e9ab
work_keys_str_mv	AT aparnagudlur calciumsensingbythestim1erluminaldomain AT anaelizazeraik calciumsensingbythestim1erluminaldomain AT nupurahirve calciumsensingbythestim1erluminaldomain AT vrajanikanth calciumsensingbythestim1erluminaldomain AT andreyabobkov calciumsensingbythestim1erluminaldomain AT guolinma calciumsensingbythestim1erluminaldomain AT sisizheng calciumsensingbythestim1erluminaldomain AT youjunwang calciumsensingbythestim1erluminaldomain AT yubinzhou calciumsensingbythestim1erluminaldomain AT elizabethakomives calciumsensingbythestim1erluminaldomain AT patrickghogan calciumsensingbythestim1erluminaldomain
_version_	1718387023469871104

Calcium sensing by the STIM1 ER-luminal domain

Ejemplares similares