Calcium sensing by the STIM1 ER-luminal domain

Calcium sensing by the STIM1 ER-luminal domain

Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.

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Bibliographic Details
Main Authors: Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, V. Rajanikanth, Andrey A. Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth A. Komives, Patrick G. Hogan
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/500001afbcee44e78123ce02e0c9e9ab
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Internet

https://doaj.org/article/500001afbcee44e78123ce02e0c9e9ab

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