Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer
Archana Monie1, Chien-Fu Hung1,2, Richard Roden1,2,4, T-C Wu1,2,3,41Departments of Pathology, 2Obstetrics and Gynecology, 3Molecular Microbiology and Immunology, and 4Oncology, 5Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USAAbstract: Cervical cancer conti...
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Dove Medical Press
2008
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oai:doaj.org-article:50025eee55f54ce89959a6bc8ee34d452021-12-02T01:56:54ZCervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer1177-54751177-5491https://doaj.org/article/50025eee55f54ce89959a6bc8ee34d452008-03-01T00:00:00Zhttp://www.dovepress.com/cervarixtrade-a-vaccine-for-the-prevention-of-hpv-16-18-associated-cer-a59https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Archana Monie1, Chien-Fu Hung1,2, Richard Roden1,2,4, T-C Wu1,2,3,41Departments of Pathology, 2Obstetrics and Gynecology, 3Molecular Microbiology and Immunology, and 4Oncology, 5Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USAAbstract: Cervical cancer continues to be the second largest cause of cancer deaths in women worldwide. Persistent infection with high-risk types of human papillomavirus (HPV) is a necessary cause of cervical cancer. Thus, prophylactic vaccination against HPV is an attractive strategy to prevent cervical cancer. Current strategies for the development of safe and effective preventive vaccines are based on the induction of neutralizing antibodies against the major capsid protein, L1 of HPV. Cervarix™ is one of the preventive HPV vaccines that has been approved in the Europe and Australia and is currently under review by the US Food and Drug Administration. Cervarix is composed of HPV16 and HPV18 L1 virus-like particles (VLPs) formulated in ASO4 adjuvant. Vaccination with Cervarix has been shown to protect women against a high proportion of precursor lesions of cervical cancer caused by these two HPV types. This review explores the various features of this new vaccine candidate and discusses the future directions in the field of HPV vaccine development.Keywords: HPV, L1, VLP, vaccine, Cervarix Archana MonieChien-Fu HungRichard RodenT-C WuDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 1, Pp 107-113 (2008) |
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DOAJ |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Archana Monie Chien-Fu Hung Richard Roden T-C Wu Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer |
| description |
Archana Monie1, Chien-Fu Hung1,2, Richard Roden1,2,4, T-C Wu1,2,3,41Departments of Pathology, 2Obstetrics and Gynecology, 3Molecular Microbiology and Immunology, and 4Oncology, 5Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USAAbstract: Cervical cancer continues to be the second largest cause of cancer deaths in women worldwide. Persistent infection with high-risk types of human papillomavirus (HPV) is a necessary cause of cervical cancer. Thus, prophylactic vaccination against HPV is an attractive strategy to prevent cervical cancer. Current strategies for the development of safe and effective preventive vaccines are based on the induction of neutralizing antibodies against the major capsid protein, L1 of HPV. Cervarix™ is one of the preventive HPV vaccines that has been approved in the Europe and Australia and is currently under review by the US Food and Drug Administration. Cervarix is composed of HPV16 and HPV18 L1 virus-like particles (VLPs) formulated in ASO4 adjuvant. Vaccination with Cervarix has been shown to protect women against a high proportion of precursor lesions of cervical cancer caused by these two HPV types. This review explores the various features of this new vaccine candidate and discusses the future directions in the field of HPV vaccine development.Keywords: HPV, L1, VLP, vaccine, Cervarix |
| format |
article |
| author |
Archana Monie Chien-Fu Hung Richard Roden T-C Wu |
| author_facet |
Archana Monie Chien-Fu Hung Richard Roden T-C Wu |
| author_sort |
Archana Monie |
| title |
Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer |
| title_short |
Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer |
| title_full |
Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer |
| title_fullStr |
Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer |
| title_full_unstemmed |
Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer |
| title_sort |
cervarix™: a vaccine for the prevention of hpv 16, 18-associated cervical cancer |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/50025eee55f54ce89959a6bc8ee34d45 |
| work_keys_str_mv |
AT archanamonie cervarixamptradeavaccineforthepreventionofhpv1618associatedcervicalcancer AT chienfuhung cervarixamptradeavaccineforthepreventionofhpv1618associatedcervicalcancer AT richardroden cervarixamptradeavaccineforthepreventionofhpv1618associatedcervicalcancer AT tcwu cervarixamptradeavaccineforthepreventionofhpv1618associatedcervicalcancer |
| _version_ |
1718402773762965504 |