Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model

Chronic kidney disease (CKD) is defined as structural and functional abnormalities of the kidney due to inflammation and fibrosis. We investigated the therapeutic effects of exosomes secreted by melatonin-stimulated mesenchymal stem cells (Exocue) on the functional recovery of the kidney in a CKD mo...

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Autores principales:	Ji-Hye Yea, Yeo Min Yoon, Jun Hee Lee, Chul Won Yun, Sang Hun Lee
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/50035a66ef514ffebbe1124066843163
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spelling	oai:doaj.org-article:50035a66ef514ffebbe11240668431632021-12-01T00:05:55ZExosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model2041-731410.1177/20417314211059624https://doaj.org/article/50035a66ef514ffebbe11240668431632021-11-01T00:00:00Zhttps://doi.org/10.1177/20417314211059624https://doaj.org/toc/2041-7314Chronic kidney disease (CKD) is defined as structural and functional abnormalities of the kidney due to inflammation and fibrosis. We investigated the therapeutic effects of exosomes secreted by melatonin-stimulated mesenchymal stem cells (Exocue) on the functional recovery of the kidney in a CKD mouse model. Exocue upregulated gene expression of micro RNAs (miRNAs) associated with anti-inflammatory and anti-fibrotic effects. Exocue-treated groups exhibited low tumor necrosis factor-α and transforming growth factor-β levels in serum and fibrosis inhibition in kidney tissues mediated through regulation of cell apoptosis and proliferation of fibrosis-related cells. Exocue treatment decreased the gene expression of CKD progression-related miRNAs. Moreover, the CKD severity was alleviated in the Exocue group via upregulation of aquaporin 2 and 5 levels and reduction of blood urea nitrogen and creatinine, resulting in functional recovery of the kidney. In conclusion, Exocue could be a novel therapeutic agent for treating CKD by regulating inflammation and fibrosis.Ji-Hye YeaYeo Min YoonJun Hee LeeChul Won YunSang Hun LeeSAGE PublishingarticleBiochemistryQD415-436ENJournal of Tissue Engineering, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biochemistry QD415-436
spellingShingle	Biochemistry QD415-436 Ji-Hye Yea Yeo Min Yoon Jun Hee Lee Chul Won Yun Sang Hun Lee Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
description	Chronic kidney disease (CKD) is defined as structural and functional abnormalities of the kidney due to inflammation and fibrosis. We investigated the therapeutic effects of exosomes secreted by melatonin-stimulated mesenchymal stem cells (Exocue) on the functional recovery of the kidney in a CKD mouse model. Exocue upregulated gene expression of micro RNAs (miRNAs) associated with anti-inflammatory and anti-fibrotic effects. Exocue-treated groups exhibited low tumor necrosis factor-α and transforming growth factor-β levels in serum and fibrosis inhibition in kidney tissues mediated through regulation of cell apoptosis and proliferation of fibrosis-related cells. Exocue treatment decreased the gene expression of CKD progression-related miRNAs. Moreover, the CKD severity was alleviated in the Exocue group via upregulation of aquaporin 2 and 5 levels and reduction of blood urea nitrogen and creatinine, resulting in functional recovery of the kidney. In conclusion, Exocue could be a novel therapeutic agent for treating CKD by regulating inflammation and fibrosis.
format	article
author	Ji-Hye Yea Yeo Min Yoon Jun Hee Lee Chul Won Yun Sang Hun Lee
author_facet	Ji-Hye Yea Yeo Min Yoon Jun Hee Lee Chul Won Yun Sang Hun Lee
author_sort	Ji-Hye Yea
title	Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
title_short	Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
title_full	Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
title_fullStr	Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
title_full_unstemmed	Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
title_sort	exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/50035a66ef514ffebbe1124066843163
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Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model

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