Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review

Musculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton’s jelly-der...

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Autores principales:	Benjamin J. Main, Nicola Maffulli, Josiah A. Valk, Hugo C. Rodriguez, Manu Gupta, Saadiq F. El-Amin, Ashim Gupta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	umbilical cord Wharton’s jelly regenerative medicine mesenchymal stem cells mesenchymal stromal cells Wharton’s jelly mesenchymal stem cells Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/500dd8f8a81843b3af7c6294072e71dd
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spelling	oai:doaj.org-article:500dd8f8a81843b3af7c6294072e71dd2021-11-25T18:39:15ZUmbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review10.3390/ph141110901424-8247https://doaj.org/article/500dd8f8a81843b3af7c6294072e71dd2021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1090https://doaj.org/toc/1424-8247Musculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton’s jelly-derived mesenchymal stem cells (WJSCs) are some of these. This review reports the clinical and functional outcomes of the applications of WJSCs in orthopedic surgery. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The studies that used culture-expanded, mesenchymal stem or stromal cells, MSCs and/or connective tissues procured from Wharton’s jelly (WJ), from January 2010 to October 2021, were included. Conventional non-operative therapies and placebos were used as comparisons. Six studies that directly discussed WJSCs use in an animal model or the basic scientific testing using an injury model were identified. Five publications studied cartilage injury, three studied degenerative disc disease, one was related to osteoarthritis, and one was related to osteochondral defects. The results of these studies suggested the benefits of WJSCs in the management of these orthopedic pathologies. To adequately assess the safety and efficacy of WJSCs in orthopedic surgery, further randomized controlled clinical studies are necessary.Benjamin J. MainNicola MaffulliJosiah A. ValkHugo C. RodriguezManu GuptaSaadiq F. El-AminAshim GuptaMDPI AGarticleumbilical cordWharton’s jellyregenerative medicinemesenchymal stem cellsmesenchymal stromal cellsWharton’s jelly mesenchymal stem cellsMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1090, p 1090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	umbilical cord Wharton’s jelly regenerative medicine mesenchymal stem cells mesenchymal stromal cells Wharton’s jelly mesenchymal stem cells Medicine R Pharmacy and materia medica RS1-441
spellingShingle	umbilical cord Wharton’s jelly regenerative medicine mesenchymal stem cells mesenchymal stromal cells Wharton’s jelly mesenchymal stem cells Medicine R Pharmacy and materia medica RS1-441 Benjamin J. Main Nicola Maffulli Josiah A. Valk Hugo C. Rodriguez Manu Gupta Saadiq F. El-Amin Ashim Gupta Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
description	Musculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton’s jelly-derived mesenchymal stem cells (WJSCs) are some of these. This review reports the clinical and functional outcomes of the applications of WJSCs in orthopedic surgery. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The studies that used culture-expanded, mesenchymal stem or stromal cells, MSCs and/or connective tissues procured from Wharton’s jelly (WJ), from January 2010 to October 2021, were included. Conventional non-operative therapies and placebos were used as comparisons. Six studies that directly discussed WJSCs use in an animal model or the basic scientific testing using an injury model were identified. Five publications studied cartilage injury, three studied degenerative disc disease, one was related to osteoarthritis, and one was related to osteochondral defects. The results of these studies suggested the benefits of WJSCs in the management of these orthopedic pathologies. To adequately assess the safety and efficacy of WJSCs in orthopedic surgery, further randomized controlled clinical studies are necessary.
format	article
author	Benjamin J. Main Nicola Maffulli Josiah A. Valk Hugo C. Rodriguez Manu Gupta Saadiq F. El-Amin Ashim Gupta
author_facet	Benjamin J. Main Nicola Maffulli Josiah A. Valk Hugo C. Rodriguez Manu Gupta Saadiq F. El-Amin Ashim Gupta
author_sort	Benjamin J. Main
title	Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
title_short	Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
title_full	Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
title_fullStr	Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
title_full_unstemmed	Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
title_sort	umbilical cord-derived wharton’s jelly for regenerative medicine applications: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/500dd8f8a81843b3af7c6294072e71dd
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Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review

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