Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

Chronic infections of the fallopian tubes with Chlamydia trachomatis can cause scarring and infertility. Here, the authors show that the pathogen alters stem cell differentiation and DNA methylation in human fallopian tube organoids, suggesting a potential link to cellular ageing and malignant trans...

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Autores principales:	Mirjana Kessler, Karen Hoffmann, Kristin Fritsche, Volker Brinkmann, Hans-Joachim Mollenkopf, Oliver Thieck, Ana Rita Teixeira da Costa, Elena I. Braicu, Jalid Sehouli, Mandy Mangler, Hilmar Berger, Thomas F. Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/500f18ebcdd2438f989609ef929e9def
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spelling	oai:doaj.org-article:500f18ebcdd2438f989609ef929e9def2021-12-02T15:35:15ZChronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation10.1038/s41467-019-09144-72041-1723https://doaj.org/article/500f18ebcdd2438f989609ef929e9def2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09144-7https://doaj.org/toc/2041-1723Chronic infections of the fallopian tubes with Chlamydia trachomatis can cause scarring and infertility. Here, the authors show that the pathogen alters stem cell differentiation and DNA methylation in human fallopian tube organoids, suggesting a potential link to cellular ageing and malignant transformation.Mirjana KesslerKaren HoffmannKristin FritscheVolker BrinkmannHans-Joachim MollenkopfOliver ThieckAna Rita Teixeira da CostaElena I. BraicuJalid SehouliMandy ManglerHilmar BergerThomas F. MeyerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mirjana Kessler Karen Hoffmann Kristin Fritsche Volker Brinkmann Hans-Joachim Mollenkopf Oliver Thieck Ana Rita Teixeira da Costa Elena I. Braicu Jalid Sehouli Mandy Mangler Hilmar Berger Thomas F. Meyer Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
description	Chronic infections of the fallopian tubes with Chlamydia trachomatis can cause scarring and infertility. Here, the authors show that the pathogen alters stem cell differentiation and DNA methylation in human fallopian tube organoids, suggesting a potential link to cellular ageing and malignant transformation.
format	article
author	Mirjana Kessler Karen Hoffmann Kristin Fritsche Volker Brinkmann Hans-Joachim Mollenkopf Oliver Thieck Ana Rita Teixeira da Costa Elena I. Braicu Jalid Sehouli Mandy Mangler Hilmar Berger Thomas F. Meyer
author_facet	Mirjana Kessler Karen Hoffmann Kristin Fritsche Volker Brinkmann Hans-Joachim Mollenkopf Oliver Thieck Ana Rita Teixeira da Costa Elena I. Braicu Jalid Sehouli Mandy Mangler Hilmar Berger Thomas F. Meyer
author_sort	Mirjana Kessler
title	Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
title_short	Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
title_full	Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
title_fullStr	Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
title_full_unstemmed	Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
title_sort	chronic chlamydia infection in human organoids increases stemness and promotes age-dependent cpg methylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/500f18ebcdd2438f989609ef929e9def
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Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

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