Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis

Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joel Jihwan Hwang, Jinhyeok Choi, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoarthritis induced pluripotent stem cell disease modeling Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5012ecf818cc449089bac8befa6eb0e5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5012ecf818cc449089bac8befa6eb0e5
record_format	dspace
spelling	oai:doaj.org-article:5012ecf818cc449089bac8befa6eb0e52021-11-25T17:10:35ZApplication of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis10.3390/cells101130322073-4409https://doaj.org/article/5012ecf818cc449089bac8befa6eb0e52021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3032https://doaj.org/toc/2073-4409Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to osteoarthritis (OA) have been performed so far, despite the high prevalence rate of degenerative joint disease. In this review, we discuss some of the most recent applications of iPSCs in disease modeling and the construction of 3D models in various fields, specifically focusing on osteoarthritis and OA-related conditions. Notably, we comprehensively reviewed the successful results of iPSC-derived disease models in recapitulating OA phenotypes for both OA and early-onset OA to encompass their broad etiology. Moreover, the latest publications with protocols that have used iPSCs to construct 3D models in recapitulating various conditions, particularly the OA environment, were further discussed. With the overall optimistic results seen in both fields, iPSCs are expected to be more widely used for OA disease modeling and 3D model construction, which could further expand OA drug screening, risk assessment, and therapeutic capabilities.Joel Jihwan HwangJinhyeok ChoiYeri Alice RimYoojun NamJi Hyeon JuMDPI AGarticleosteoarthritisinduced pluripotent stem celldisease modelingBiology (General)QH301-705.5ENCells, Vol 10, Iss 3032, p 3032 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis induced pluripotent stem cell disease modeling Biology (General) QH301-705.5
spellingShingle	osteoarthritis induced pluripotent stem cell disease modeling Biology (General) QH301-705.5 Joel Jihwan Hwang Jinhyeok Choi Yeri Alice Rim Yoojun Nam Ji Hyeon Ju Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
description	Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to osteoarthritis (OA) have been performed so far, despite the high prevalence rate of degenerative joint disease. In this review, we discuss some of the most recent applications of iPSCs in disease modeling and the construction of 3D models in various fields, specifically focusing on osteoarthritis and OA-related conditions. Notably, we comprehensively reviewed the successful results of iPSC-derived disease models in recapitulating OA phenotypes for both OA and early-onset OA to encompass their broad etiology. Moreover, the latest publications with protocols that have used iPSCs to construct 3D models in recapitulating various conditions, particularly the OA environment, were further discussed. With the overall optimistic results seen in both fields, iPSCs are expected to be more widely used for OA disease modeling and 3D model construction, which could further expand OA drug screening, risk assessment, and therapeutic capabilities.
format	article
author	Joel Jihwan Hwang Jinhyeok Choi Yeri Alice Rim Yoojun Nam Ji Hyeon Ju
author_facet	Joel Jihwan Hwang Jinhyeok Choi Yeri Alice Rim Yoojun Nam Ji Hyeon Ju
author_sort	Joel Jihwan Hwang
title	Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
title_short	Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
title_full	Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
title_fullStr	Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
title_full_unstemmed	Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
title_sort	application of induced pluripotent stem cells for disease modeling and 3d model construction: focus on osteoarthritis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5012ecf818cc449089bac8befa6eb0e5
work_keys_str_mv	AT joeljihwanhwang applicationofinducedpluripotentstemcellsfordiseasemodelingand3dmodelconstructionfocusonosteoarthritis AT jinhyeokchoi applicationofinducedpluripotentstemcellsfordiseasemodelingand3dmodelconstructionfocusonosteoarthritis AT yerialicerim applicationofinducedpluripotentstemcellsfordiseasemodelingand3dmodelconstructionfocusonosteoarthritis AT yoojunnam applicationofinducedpluripotentstemcellsfordiseasemodelingand3dmodelconstructionfocusonosteoarthritis AT jihyeonju applicationofinducedpluripotentstemcellsfordiseasemodelingand3dmodelconstructionfocusonosteoarthritis
_version_	1718412647587643392

Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis

Ejemplares similares