Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.

Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-2...

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Autores principales:	Karlo D T Natividad, Simon R Junankar, Norhanani Mohd Redzwan, Radhika Nair, Rushika C Wirasinha, Cecile King, Robert Brink, Alexander Swarbrick, Marcel Batten
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5013b632422a4d79b8f418f45485d116
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spelling	oai:doaj.org-article:5013b632422a4d79b8f418f45485d1162021-11-18T07:53:52ZInterleukin-27 signaling promotes immunity against endogenously arising murine tumors.1932-620310.1371/journal.pone.0057469https://doaj.org/article/5013b632422a4d79b8f418f45485d1162013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23554861/?tool=EBIhttps://doaj.org/toc/1932-6203Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor α (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-γ production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (Treg). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent.Karlo D T NatividadSimon R JunankarNorhanani Mohd RedzwanRadhika NairRushika C WirasinhaCecile KingRobert BrinkAlexander SwarbrickMarcel BattenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57469 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karlo D T Natividad Simon R Junankar Norhanani Mohd Redzwan Radhika Nair Rushika C Wirasinha Cecile King Robert Brink Alexander Swarbrick Marcel Batten Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
description	Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor α (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-γ production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (Treg). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent.
format	article
author	Karlo D T Natividad Simon R Junankar Norhanani Mohd Redzwan Radhika Nair Rushika C Wirasinha Cecile King Robert Brink Alexander Swarbrick Marcel Batten
author_facet	Karlo D T Natividad Simon R Junankar Norhanani Mohd Redzwan Radhika Nair Rushika C Wirasinha Cecile King Robert Brink Alexander Swarbrick Marcel Batten
author_sort	Karlo D T Natividad
title	Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
title_short	Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
title_full	Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
title_fullStr	Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
title_full_unstemmed	Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
title_sort	interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5013b632422a4d79b8f418f45485d116
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Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.

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