Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenviron...

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Auteurs principaux:	Florian Wimmers, Nikita Subedi, Nicole van Buuringen, Daan Heister, Judith Vivié, Inge Beeren-Reinieren, Rob Woestenenk, Harry Dolstra, Aigars Piruska, Joannes F. M. Jacobs, Alexander van Oudenaarden, Carl G. Figdor, Wilhelm T. S. Huck, I. Jolanda M. de Vries, Jurjen Tel
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/5014ff7f8a254b8ab188443ef63dba4a
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spelling	oai:doaj.org-article:5014ff7f8a254b8ab188443ef63dba4a2021-12-02T17:32:18ZSingle-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells10.1038/s41467-018-05784-32041-1723https://doaj.org/article/5014ff7f8a254b8ab188443ef63dba4a2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05784-3https://doaj.org/toc/2041-1723Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.Florian WimmersNikita SubediNicole van BuuringenDaan HeisterJudith ViviéInge Beeren-ReinierenRob WoestenenkHarry DolstraAigars PiruskaJoannes F. M. JacobsAlexander van OudenaardenCarl G. FigdorWilhelm T. S. HuckI. Jolanda M. de VriesJurjen TelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Wimmers Nikita Subedi Nicole van Buuringen Daan Heister Judith Vivié Inge Beeren-Reinieren Rob Woestenenk Harry Dolstra Aigars Piruska Joannes F. M. Jacobs Alexander van Oudenaarden Carl G. Figdor Wilhelm T. S. Huck I. Jolanda M. de Vries Jurjen Tel Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
description	Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.
format	article
author	Florian Wimmers Nikita Subedi Nicole van Buuringen Daan Heister Judith Vivié Inge Beeren-Reinieren Rob Woestenenk Harry Dolstra Aigars Piruska Joannes F. M. Jacobs Alexander van Oudenaarden Carl G. Figdor Wilhelm T. S. Huck I. Jolanda M. de Vries Jurjen Tel
author_facet	Florian Wimmers Nikita Subedi Nicole van Buuringen Daan Heister Judith Vivié Inge Beeren-Reinieren Rob Woestenenk Harry Dolstra Aigars Piruska Joannes F. M. Jacobs Alexander van Oudenaarden Carl G. Figdor Wilhelm T. S. Huck I. Jolanda M. de Vries Jurjen Tel
author_sort	Florian Wimmers
title	Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
title_short	Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
title_full	Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
title_fullStr	Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
title_full_unstemmed	Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
title_sort	single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5014ff7f8a254b8ab188443ef63dba4a
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Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

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